Evidence map›Paper›PMID 40512914›Full record

ArticleOptics letters2025

OCT in dermatology: a process for determining whether a fully diversified dataset is needed for AI model-building.

Qiuyun Xu, Amanda P Siegel, Josee M D Smith, Joseph W Fakhoury, Maria Tsoukas, Hayden Smith, Chiu-Lan Chen, Steven Daveluy, Darius Mehregan, Julia Welzel and 2 more

Abstract read
In one paragraph

Article in Optics letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qiuyun Xu
Amanda P Siegel
Josee M D Smith
Joseph W Fakhoury
Maria Tsoukas
Hayden Smith
Chiu-Lan Chen
Steven Daveluy
Darius Mehregan
Julia Welzel
Eric R Tkaczyk
Kamran Avanaki

Funding

CSRD VA I01 CX002721CSRD VA IK2 CX001785
6 · The paper itself

Abstract

Optical coherence tomography (OCT) has sufficient depth penetration for detection of skin pathologies, but its detection effectiveness can be aided by the assistance of artificial intelligence (AI) modeling. AI model-building identifies pathologies by comparing images from healthy and diseased tissues, but healthy skin can present as quite variable across skin types and ages. Here, we selected a commonly used parameter for skin analysis and attenuation coefficient and analyzed how it varied in the dermis and epidermis, and in skin-exposed and skin-protected regions, for 100 subjects from a wide range of skin types (Fitzpatrick types I-V) and ages (13-83). For the statistical analysis, we report whether comparisons of the dermis and epidermis and sun-exposed and sun-protected areas across age and skin type are statistically significant, indeterminate, or not statistically significant and present 95% confidence intervals for this parameter as it ranges across different ages and skin types. This process of pre-analyzing features using healthy images provides a roadmap for how to ease the recruitment process while acquiring a sufficient range of images for effective AI model-building. We expect this type of analysis can have the effect of accelerating translation of AI-based OCT image analysis to the clinic.

Indexed as

Artificial IntelligenceDermatologySkinTomography, Optical CoherenceAdolescentAdultAgedAged, 80 and overFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedYoung Adult

Identifiers

PMID40512914
PMCPMC12317784

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.