Evidence map›Paper›PMID 40512855›Full record

ArticleScience advances2025

Armored human CAR T

Dominic A Boardman, Sonya Mangat, Jana K Gillies, Lorna Leon, Vivian C W Fung, Manjurul Haque, Majid Mojibian, Torin Halvorson, Qing Huang, Karoliina Tuomela and 4 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. CAR-mediated release of IL-10 increases the function of regulatory T cells: Relevance for future clinical application.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. From rough to refined: Applying diamond standards to CAR Treg development.Molecular therapy. Methods & clinical development · 2025
    Article
  11. 3-in-oneiScience · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Dominic A BoardmanDepartment of Surgery, The University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0001-7387-8293
Sonya MangatDepartment of Surgery, The University of British Columbia, Vancouver, BC, Canada.ORCID 0009-0000-3809-3079
Jana K GilliesDepartment of Surgery, The University of British Columbia, Vancouver, BC, Canada.
Lorna LeonDepartment of Surgery, The University of British Columbia, Vancouver, BC, Canada.
Vivian C W FungDepartment of Surgery, The University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0001-5023-5092
Manjurul HaqueDepartment of Surgery, The University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0002-9838-0667
Majid MojibianDepartment of Surgery, The University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0002-1595-9068
Torin HalvorsonDepartment of Surgery, The University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0003-4698-2479
Qing HuangDepartment of Surgery, The University of British Columbia, Vancouver, BC, Canada.
Karoliina TuomelaDepartment of Surgery, The University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0003-1631-7435
Christine M WardellDepartment of Surgery, The University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0002-2418-5076
Andrew BrownDepartment of Surgery, The University of British Columbia, Vancouver, BC, Canada.
Avery J LamDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID 0000-0001-7794-1325
Megan K LevingsDepartment of Surgery, The University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0002-0305-5790

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulatory T cell (T

Indexed as

Interleukin-10Programmed Cell Death 1 ReceptorPromoter Regions, GeneticReceptors, Chimeric AntigenT-Lymphocytes, RegulatoryAnimalsCRISPR-Cas SystemsDendritic CellsHumansImmunotherapy, AdoptiveMiceIL10 protein, humanInterleukin-10PDCD1 protein, humanProgrammed Cell Death 1 ReceptorReceptors, Chimeric Antigen

Identifiers

PMID40512855
PMCPMC12164974

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.