ArticleScience advances2025
A phosphorylation-driven ubiquitination switch fine-tunes Alfin-like 7-induced ROS signaling in plant immunity.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Decoding MAPK cascades in plant immunity: Activation, regulation, integration, and pathogen manipulation.Journal of integrative plant biology · 2026Review
- GhCOR27 confers Verticillium wilt resistance in cotton by relieving the GhASIL1-GhERF114-mediated repression of lignin accumulation.Plant physiology · 2026Article
- MdRLKT1-MdRAX2-MdMKS1 Module Positively Regulating Resistance to Cytospora mali in Apple.Plant biotechnology journal · 2026Article
- FBXL8 Stabilizes IκBα and Negatively Regulated NF-κB Activation to Suppress Pancreatic Cancer Progression.International journal of biological sciences · 2026Article
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Authors and funding
14 authors.
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Abstract
Maintaining reactive oxygen species (ROS) homeostasis is essential for balancing growth-defense trade-offs in plants. Although the transcription factors (TFs) that regulate ROS production and scavenging genes have been studied, the regulation of these TFs to control ROS accumulation remains poorly understood. Here, we demonstrate that during N nucleotide-binding leucine-rich repeat-mediated immunity, Alfin-like 7 (AL7) is ubiquitinated by the ubiquitin protein ligase E3 component N-recognin 7 (UBR7). UBR7 interacts with AL7 and acts as a molecular brake to mediate the ubiquitination of AL7 at lysine-20, leading to its subsequent proteasomal degradation. UBR7 functions upstream of AL7 to reduce AL7-induced ROS accumulation during
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