ArticleScience advances2025
Top-down attention and Alzheimer's pathology affect cortical selectivity during learning, influencing episodic memory in older adults.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Plasma proteomic signatures of preclinical Alzheimer's disease in clinically unimpaired older adults.Molecular neurodegeneration · 2026Article
- Dysfunction of the episodic memory network in the Alzheimer's disease cascade.Nature communications · 2026Article
- Age-related differences in spatial memory occur alongside reduced visual fMRI BOLD but preserved viewpoint-specific scene representations.bioRxiv : the preprint server for biology · 2026Article
- The relationship between category-level neural differentiation and exploratory eye movements in healthy young and older adults.Neurobiology of aging · 2025Article
- Long-read genome sequencing and multi-omics in aging and neurodegeneration.medRxiv : the preprint server for health sciences · 2025Article
- Synergistic effects ofbioRxiv : the preprint server for biology · 2025Article
- Attending to Remember: Recent Advances in Methods and Theory.Current directions in psychological science · 2025Article
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Abstract
Effective memory formation declines in human aging. Diminished neural selectivity-reduced differential responses to preferred versus nonpreferred stimuli-may contribute to memory decline, but its drivers remain unclear. We investigated the effects of top-down attention and preclinical Alzheimer's disease (AD) pathology on neural selectivity in 166 cognitively unimpaired older participants using functional magnetic resonance imaging during a word-face/word-place associative memory task. During learning, neural selectivity in place- and, to a lesser extent, face-selective regions was greater for subsequently remembered than forgotten events; positively scaled with variability in dorsal attention network activity, within and across individuals; and negatively related to AD pathology, evidenced by elevated plasma phosphorylated Tau
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