Evidence map›Paper›PMID 40512814›Full record

ArticleAging cell2025

Cerebral Metabolic Rate of Oxygen and Accelerometry-Based Fatigability in Community-Dwelling Older Adults.

Emma L Gay, Caterina Rosano, Paul M Coen, Nicholaas Bohnen, Theodore Huppert, Yujia Susanna Qiao, Nancy W Glynn

Abstract read
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Emma L GayDepartment of Epidemiology, University of Pittsburgh, School of Public Health, Pittsburgh, Pennsylvania, USA.
Caterina RosanoDepartment of Epidemiology, University of Pittsburgh, School of Public Health, Pittsburgh, Pennsylvania, USA.
Paul M CoenAdventHealth, Translational Research Institute, Orlando, Florida, USA.
Nicholaas BohnenDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Theodore HuppertDepartment of Electrical and Computer Engineering, University of Pittsburgh, Swanson School of Engineering, Pittsburgh, Pennsylvania, USA.
Yujia Susanna QiaoDepartment of Epidemiology, University of Pittsburgh, School of Public Health, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-7356-3320
Nancy W GlynnDepartment of Epidemiology, University of Pittsburgh, School of Public Health, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-2265-0162

Funding

Study of Muscle, Mobility and Aging: SOMMA2R01AG059416 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI STEVEN RON CUMMINGS, Peggy Mannen Cawthon · 2018 to 2026
$70.3M
Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LEON LENCHIK · 2002 to 2026
$36.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
TRAINING IN THE EPIDEMIOLOGY OF AGINGT32AG000181 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 1989 to 2025
$6.2M
Neurobiological drivers of mobility resilience: the dopaminergic systemU01AG061393 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BOHNEN, NICOLAAS IDA, ROSANO, CATERINA · 2018 to 2022
$6.2M
Neural and Energetic Drivers of Performance and Perceived Fatigability in Older AdultsR01AG075025 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROSANO, CATERINA · 2022 to 2025
$2.5M
NCATS NIH HHS UL1 TR001420NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG 059416NIA NIH HHS R01 AG059416NIA NIH HHS R01 AG075025NIA NIH HHS R01AG075025NIA NIH HHS T32 AG000181NIA NIH HHS U01 AG061393NIA NIH HHS U01AG061393
6 · The paper itself

Abstract

Alterations in energy metabolism may drive fatigue in older age, but prior research primarily focused on skeletal muscle energetics without assessing other systems and utilized self-reported measures of fatigue. We tested the association between energy metabolism in the brain and an objective measure of fatigability in the Study of Muscle, Mobility and Aging (N = 119, age 76.8 ± 4.0 years, 59.7% women). Total brain cerebral metabolic rate of oxygen (CMRO

Indexed as

brain energeticscardiorespiratory fitnessfatiguephysical performanceskeletal muscle energetics

Identifiers

PMID40512814
PMCPMC12341810

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.