Evidence map›Paper›PMID 40512793›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

RACK1 promotes the development and function of alveolar macrophages through directly binding to and stabilizing PPARγ.

Hui Jiang, Hongfang Yun, Xu Wang, Zhuo Shen, Genyu Liu, Tao Zou, Tingting Guo, Mengyao Wu, Yuchen Lu, Lijiao Deng and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hui Jiang *Beijing Institute of Basic Medical Sciences, Beijing 100850, China.ORCID 0000-0001-7176-0822
Hongfang Yun *Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
Xu Wang *Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
Zhuo ShenBeijing Institute of Basic Medical Sciences, Beijing 100850, China.
Genyu LiuBeijing Institute of Basic Medical Sciences, Beijing 100850, China.
Tao ZouBeijing Institute of Basic Medical Sciences, Beijing 100850, China.
Tingting GuoBeijing Institute of Basic Medical Sciences, Beijing 100850, China.
Mengyao WuBeijing Institute of Basic Medical Sciences, Beijing 100850, China.ORCID 0000-0001-5233-0851
Yuchen LuBeijing Institute of Basic Medical Sciences, Beijing 100850, China.
Lijiao DengBeijing Institute of Basic Medical Sciences, Beijing 100850, China.
Ju MiaoBeijing Institute of Basic Medical Sciences, Beijing 100850, China.
Hongbin DengInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.ORCID 0000-0002-4398-8819
Zengqiang YuanBeijing Institute of Basic Medical Sciences, Beijing 100850, China.
Jiyan ZhangBeijing Institute of Basic Medical Sciences, Beijing 100850, China.ORCID 0000-0002-8649-8035

Funding

MOST | National Natural Science Foundation of China (NSFC) 81930027MOST | National Natural Science Foundation of China (NSFC) 92169207
6 · The paper itself

Abstract

Alveolar macrophages (AMs) are indispensable to prevent pulmonary alveolar proteinosis and clear inhaled pathogens. Receptor for activated C kinase 1 (RACK1) is a versatile adaptor protein that regulates multiple signaling pathways. Whether RACK1 is implicated in AM alterations remains elusive. Alveolar type 2 cells-derived granulocyte-macrophage colony-stimulating factor and autocrine transforming growth factor-β1 drive the transcription of

Indexed as

Macrophages, AlveolarNeoplasm ProteinsPPAR gammaReceptors for Activated C KinaseAnimalsCell DifferentiationMiceMice, Inbred C57BLMice, KnockoutProtein BindingSignal TransductionNeoplasm ProteinsPPAR gammaPparg protein, mouseRACK1 protein, mouseReceptors for Activated C Kinasealveolar macrophagesinteractionPPARγRACK1stability

Identifiers

PMID40512793
PMCPMC12184504

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.