ArticlePloS one2025
The effects of multimodal cocktail analgesic local injection in postoperative pain control after laminoplasty: A study protocol of a prospective randomized controlled trial.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06113497 (A Prospective Study on the Comparison of Postoperative Pain According to the Use of Cocktail Therapy in Laminoplasty), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Study on the Comparison of Postoperative Pain According to the Use of Cocktail Therapy in Laminoplasty
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLaminoplasty is the most widely used surgical technique for cervical spondylotic myelopathy. This surgery can cause severe postoperative pain; if not controlled, recovery or rehabilitation may be delayed. Therefore, effective control of postoperative pain is crucial. This randomized prospective study aims to evaluate the effects of a multimodal cocktail injection on postoperative pain and the efficacy of the protocol in patients undergoing posterior laminoplasty for cervical myelopathy.
methodsThis single-center prospective randomized controlled trial focuses on patients diagnosed with cervical myelopathy or radiculopathy. This study will include patients aged 20-80 years who underwent laminoplasty. Participants will be divided into two groups: one group will receive a multimodal cocktail local injection during surgery and the other group will receive a local injection of normal saline only. The study is scheduled for a 3 month follow-up. The primary outcome measure will be the visual analog scale (VAS) score. Secondary outcome measures will be opioid and rescue analgesic consumption, time of initial analgesic requirement, adverse effects, and Japanese Orthopaedic Association (JOA) and neck disability index (NDI) scores. RESULTS AND
conclusionsThis is the first prospective randomized controlled trial to analyze the effects and safety of multimodal cocktail injections after cervical laminoplasty. Through this study, we anticipate that the demonstration of potential usefulness of multimodal cocktail analgesic injections in various aspects of spinal surgery, thereby this will provide a protocol for intraoperative cocktail injection.
trial registrationThis trial was registered at the (https://www.clinicaltrial.gov), (NCT06113497) on 11/12/2023.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.