Evidence map›Paper›PMID 40512623›Full record

ArticleCell reports2025

Edinger-Westphal Urocortin-1 neurons regulate consumption and affect.

Rebecca J Bluett, Ying Yu, Jordan L Pauli, Carlos A Campos, Richard D Palmiter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rebecca J BluettDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA. Electronic address: rjblu8@uw.edu.
Ying YuDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
Jordan L PauliDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
Carlos A CamposDepartment of Medicine & Diabetes Institute, University of Washington, Seattle, WA 98195, USA.
Richard D PalmiterDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address: palmiter@uw.edu.

Funding

Therapeutic Potential of Kappa Antagonists in the Adjunctive Treatment of Psychotic DepressionP50MH106428 · NIMH · UNIVERSITY OF WASHINGTON · PI CHAVKIN, CHARLES · 2015 to 2019
$7.6M
Dissecting Viscerosensory Pathways Controlling Feeding BehaviorK01DK124245 · NIDDK · UNIVERSITY OF WASHINGTON · PI CAMPOS, CARLOS A · 2020 to 2024
$749k
NIDDK NIH HHS K01 DK124245NIMH NIH HHS P50 MH106428
6 · The paper itself

Abstract

Affective and consumption circuits in the brain are intertwined, with changes in each domain often affecting the other. Therapeutic interventions that reduce consumption, thereby facilitating weight loss, have tended to increase anxiety and depression. Obesity is a major risk factor for poor health; thus, it is important to understand the circuits and signals that regulate consummatory and affective behavior. Neurons expressing Urocortin-1 (Ucn) in the Edinger-Westphal (EW) nucleus have been hypothesized to play an important role in regulating both consummatory and affective behavioral domains and responses to stress. We generated Ucn

Indexed as

AffectNeuronsUrocortinsAnimalsBehavior, AnimalMaleMiceMice, Inbred C57BLUrocortinsanxietyconsumptionCP: MetabolismCP: NeuroscienceEdinger-Westphalfiber photometryhedonic feedingoptogeneticsrewardstressUrocortin

Identifiers

PMID40512623
PMCPMC12536611

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.