ArticleCell reports2025
Airway basal stem cells are necessary for the maintenance of functional intraepithelial airway macrophages.
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Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
8 citing papers in PubMed.
- ERS Congress 2025: highlights from the Basic and Translational Sciences Assembly.ERJ open research · 2026Article
- An immune-poised state of human bronchial epithelial cells mediates defense against RSV in adults.Nature communications · 2026Article
- Beyond the epithelium: multicellular niches in lung regeneration and disease.American journal of physiology. Lung cellular and molecular physiology · 2026Review
- Live imaging of human airway epithelial repair in precision-cut lung slices after targeted cell damage.Biochemistry and biophysics reports · 2026Article
- Cellular plasticity and regenerative mechanisms in the lung.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- The immunology of asthma.Nature immunology · 2025Review
- Innate Immunity and Asthma Exacerbations: Insights From Human Models.Immunological reviews · 2025Review
- Airway basal stem cell therapy for lung diseases: an emerging regenerative medicine strategy.Stem cell research & therapy · 2025Review
Corrections and comments
- Update of
Authors and funding
36 authors.
Tristan KooistraDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Borja SaezCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Institute for Lung Health (ILH), Department of Internal Medicine, Justus-Liebig University, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), 35392 Giessen, Germany; Cardio-Pulmonary Institute (CPI), Department of Internal Medicine, Justus Liebig University, 35392 Giessen, Germany.
Marly RocheDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Alejandro Egea-ZorrillaInstitute for Lung Health (ILH), Department of Internal Medicine, Justus-Liebig University, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), 35392 Giessen, Germany; Cardio-Pulmonary Institute (CPI), Department of Internal Medicine, Justus Liebig University, 35392 Giessen, Germany.
Dongzhu LiInstitute for Lung Health (ILH), Department of Internal Medicine, Justus-Liebig University, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), 35392 Giessen, Germany; Cardio-Pulmonary Institute (CPI), Department of Internal Medicine, Justus Liebig University, 35392 Giessen, Germany.
Dilanjan AnketellDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Nhan NguyenDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Jorge VilloriaCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Jacob GillisDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Eva PetriDepartment of Regenerative Medicine, CIMA Universidad de Navarra, 31008 Pamplona, Spain.
Laura VeraDepartment of Regenerative Medicine, CIMA Universidad de Navarra, 31008 Pamplona, Spain.
Zuriñe Blasco-IturriInstitute for Lung Health (ILH), Department of Internal Medicine, Justus-Liebig University, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), 35392 Giessen, Germany; Cardio-Pulmonary Institute (CPI), Department of Internal Medicine, Justus Liebig University, 35392 Giessen, Germany; Department of Regenerative Medicine, CIMA Universidad de Navarra, 31008 Pamplona, Spain.
Neal P SmithCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Jehan AlladinaDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Yanting ZhangDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Vladimir VinarskyCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Manjunatha ShivarajuCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Susan L ShengDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Michelle ChenDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Meryem Gonzalez-CeleiroCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Hongmei MouCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; The Mucosal Immunology & Biology Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.
Avinash WaghrayCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Brian LinCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Department of Developmental, Molecular and Chemical Biology, School of Medicine, Tufts University, Boston, MA, USA.
Azadeh PaksaCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Kilangsungla YangerCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Purushotama Rao TataCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Departments of Cell Biology and Medicine, Duke Regeneration Center, Duke University School of Medicine, Durham, NC 27710, USA.
Rui ZhaoCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Benjamin CaustonDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Javier J ZuluetaDepartment of Pulmonology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Felipe ProsperDepartment of Regenerative Medicine, CIMA Universidad de Navarra, 31008 Pamplona, Spain; Department of Hematology and Cell Therapy, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Josalyn L ChoDivision of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Alexandra-Chloe VillaniCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Adam HaberDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Jayaraj RajagopalDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
Benjamin D MedoffDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. Electronic address: bmedoff@mgh.harvard.edu.
Ana Pardo-SagantaDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA; Institute for Lung Health (ILH), Department of Internal Medicine, Justus-Liebig University, Universities of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), 35392 Giessen, Germany; Cardio-Pulmonary Institute (CPI), Department of Internal Medicine, Justus Liebig University, 35392 Giessen, Germany. Electronic address: ana.pardo-saganta@innere.med.uni-giessen.de.
Funding
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI HANS-JOACHIM LEHMLER · 1990 to 2026
$40.5MResearch Training in Pulmonary Immunology and Allergy at MGHT32HL116275 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI David C Christiani, ANDREW D LUSTER · 2013 to 2026
$8.6MIntercellular communication and cell regulation in airway epithelial ensembles in regeneration and diseaseR01HL118185 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI RAJAGOPAL, JAYARAJ · 2014 to 2021
$4.2MTRAINING GRANT IN LUNG CELL &MOLECULAR BIOLOGYT32HL007874 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MEDOFF, BENJAMIN DAVID · 1997 to 2011
$4.1MProgenitors, Mechanisms of Differentiation, and Functions of Lung M CellsR01HL164563 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI RAJAGOPAL, JAYARAJ · 2022 to 2025
$3.2MMapping Airway Epithelial Cell-Immune Cell Interactions in Lung Health and DiseaseU01HL175384 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Jacques Deguine, Benjamin David Medoff · 2024 to 2026
$2.3MCenter for Regenerative Medicine (CRM) Support for New Faculty MemberP30HL101287 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SCADDEN, DAVID T · 2009 to 2010
$1.5MTrained Immunity in the Airway Mucosa Differentiates Asthma from Allergy AloneR21AI176580 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MEDOFF, BENJAMIN DAVID · 2023 to 2024
$462kRole of Intraepithelial airway macrophages in lung homeostasis and diseaseK08HL177151 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Tristan Gregory Kooistra · 2025 to 2026
$400kNHLBI NIH HHS K08 HL177151NHLBI NIH HHS P30 HL101287NHLBI NIH HHS R01 HL118185NHLBI NIH HHS R01 HL164563NHLBI NIH HHS T32 HL007874NHLBI NIH HHS T32 HL116275NHLBI NIH HHS U01 HL175384NIAID NIH HHS R21 AI176580NIEHS NIH HHS P30 ES005605
Abstract
Stem cells are known to provide signals that contribute to the maintenance and function of neighboring cells. We demonstrate that Notch signaling arising from airway basal stem cells is necessary for the function of a unique population of intraepithelial airway macrophages (IAMs) in the murine trachea. Without this stem cell signaling, IAMs lose MHC II expression, which in turn prevents antigen-induced allergic inflammation. Distal murine airways do not harbor basal stem cells, and, in this region of the lung, allergic inflammation proceeds unperturbed. We speculate that the functional coupling of specific anatomically restricted stem cell populations and adjacent immune cells is one mechanism for ensuring that inflammatory responses are compartmentalized to regions of injury. Basal stem cells are found throughout the human airway tree and we demonstrate the existence of human IAM-like cells, suggesting that their interaction may influence airways disease.
Indexed as
MacrophagesStem CellsTracheaAnimalsHistocompatibility Antigens Class IIHumansLungMiceMice, Inbred C57BLReceptors, NotchSignal TransductionHistocompatibility Antigens Class IIReceptors, Notchairway basal stem cellsallergic inflammationCP: Stem cell researchintraepithelial immune cellsmacrophagesNotch pathway
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.