Evidence map›Paper›PMID 40512617›Full record

ArticleCell reports2025

The amyloid precursor family of proteins in excitatory neurons are essential for regulating cortico-hippocampal circuit dynamics in vivo.

Samuel S Harris, Rikesh M Rajani, Jana Zünkler, Robert Ellingford, Mengke Yang, James M Rowland, Alexander Schmidt, Byung Il Lee, Marten Kehring, Mariam Hellmuth and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Samuel S HarrisUK Dementia Research Institute at University College London, London, UK. Electronic address: samuel.harris@ucl.ac.uk.
Rikesh M RajaniUK Dementia Research Institute at University College London, London, UK; British Heart Foundation - UK Dementia Research Institute Centre for Vascular Dementia Research at The University of Edinburgh, Edinburgh, UK.
Jana ZünklerUK Dementia Research Institute at University College London, London, UK.
Robert EllingfordUK Dementia Research Institute at University College London, London, UK.
Mengke YangUK Dementia Research Institute at University College London, London, UK.
James M RowlandUK Dementia Research Institute at University College London, London, UK.
Alexander SchmidtGöttingen Campus Institute for Dynamics of Biological Networks, Göttingen, Germany.
Byung Il LeeUK Dementia Research Institute at University College London, London, UK.
Marten KehringUK Dementia Research Institute at University College London, London, UK.
Mariam HellmuthUK Dementia Research Institute at University College London, London, UK.
Francesca Kar Wey LamUK Dementia Research Institute at University College London, London, UK.
Dominique FässlerDepartment of Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany.
Susanne ErdingerDepartment of Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany.
David P WolferInstitute of Anatomy, University of Zurich, Zurich, Switzerland; Institute of Human Movement Sciences and Sport, ETH Zurich, Zurich, Switzerland.
Carlo Sala FrigerioUK Dementia Research Institute at University College London, London, UK.
Fred WolfGöttingen Campus Institute for Dynamics of Biological Networks, Göttingen, Germany.
Bradley T HymanDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Ulrike C MüllerDepartment of Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany.
Marc Aurel BuscheUK Dementia Research Institute at University College London, London, UK; Department of Neurodegenerative Diseases, University Hospital of Geriatric Medicine FELIX PLATTER and University of Basel, Basel, Switzerland; Department of Biomedicine, University of Basel, Basel, Switzerland. Electronic address: m.busche@ucl.ac.uk.

Funding

Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Christine S Ritchie · 2019 to 2026
$36.5M
NIA NIH HHS P30 AG062421
6 · The paper itself

Abstract

The amyloid precursor protein (APP) family is ubiquitously expressed in the mammalian brain and implicated in Alzheimer's disease. APP family proteins participate in synaptic function and their absence impairs cognition. However, how these proteins regulate neural circuits and influence brain-behavior relationships remains unknown. Using in vivo two-photon Ca

Indexed as

Amyloid beta-Protein PrecursorCerebral CortexHippocampusNeuronsAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutNeocortexNerve Tissue ProteinsReceptors, N-Methyl-D-AspartateSynapsesAmyloid beta-Protein PrecursorNerve Tissue ProteinsReceptors, N-Methyl-D-AspartateAlzheimer’s diseaseamyloid precursor protein familycomputational modelingcortico-hippocampal circuitsCP: NeuroscienceGluN1NeuropixelsNMDAR functionslow-wave activityspontaneous neuronal activitytwo-photon Ca(2+)-imaging

Identifiers

PMID40512617
PMCPMC12309856

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.