Evidence map›Paper›PMID 40512481›Full record

ArticleACS biomaterials science & engineering2025

Mechanical Stimulation of Equine Bone Marrow Mesenchymal Stromal Cell-Derived Cartilage-Like In Vitro Model Triggers Osteoarthritis Features.

Romain Contentin, Cassie Jehl, Kevin Commenchail, Florence Legendre, Philippe Galéra, Frédéric Cassé, Magali Demoor

Abstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Romain ContentinUniversité Caen Normandie, Normandie Univ, BIOTARGEN UR7450, Normandie Equine Valée, GIS CENTAURE, F-14000 Caen, France.ORCID 0000-0001-5917-7298
Cassie JehlUniversité Caen Normandie, Normandie Univ, BIOTARGEN UR7450, Normandie Equine Valée, GIS CENTAURE, F-14000 Caen, France.
Kevin CommenchailUniversité Caen Normandie, Normandie Univ, BIOTARGEN UR7450, Normandie Equine Valée, GIS CENTAURE, F-14000 Caen, France.
Florence LegendreUniversité Caen Normandie, Normandie Univ, BIOTARGEN UR7450, Normandie Equine Valée, GIS CENTAURE, F-14000 Caen, France.ORCID 0000-0002-9951-1585
Philippe GaléraUniversité Caen Normandie, Normandie Univ, BIOTARGEN UR7450, Normandie Equine Valée, GIS CENTAURE, F-14000 Caen, France.
Frédéric CasséUniversité Caen Normandie, Normandie Univ, BIOTARGEN UR7450, Normandie Equine Valée, GIS CENTAURE, F-14000 Caen, France.ORCID 0000-0001-7991-6123
Magali DemoorUniversité Caen Normandie, Normandie Univ, BIOTARGEN UR7450, Normandie Equine Valée, GIS CENTAURE, F-14000 Caen, France.ORCID 0000-0002-8975-7055

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) affects millions of people globally, causing irreversible cartilage damage, chronic inflammation, and progressive joint dysfunction. Similarly, horses can develop OA spontaneously or due to their athletic careers, influenced by mechanical and biochemical factors. Current treatments primarily focus on symptom relief without promoting cartilage regeneration. In line with the 3Rs principles (refine, reduce, replace), the development of

Indexed as

Bone Marrow CellsMesenchymal Stem CellsOsteoarthritisAnimalsCell DifferentiationCell ProliferationCells, CulturedChondrocytesChondrogenesisGlycosaminoglycansHorsesStress, MechanicalGlycosaminoglycanschondrocytesequine cartilagein vitro modelmechanical compressionmesenchymal stromal cellsosteoarthritis

Identifiers

PMID40512481
PMCPMC12264857

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.