ReviewStem cell reviews and reports2025
Wnt10b Regulation of Hair Follicle Development, Regeneration, and Skin Diseases.
Review in Stem cell reviews and reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Organoid-loaded core-shell cryomicroneedles induce biomimetic follicular units and hair regeneration.Bioactive materials · 2026Article
- Integrative mRNA and lncRNA Transcriptome Analysis of Skin Tissues with Different Coat Types in Cashmere Goats Across Stages of Hair Follicle Development.Animals : an open access journal from MDPI · 2026Article
- Wnt Signaling Across Adult Skin Mini-Organs: Interfollicular Epidermis, Hair Follicle, and Nail-Implications for Disease and Regeneration.International journal of molecular sciences · 2026Review
- Expression dynamics and functional roles of KLF4 during embryonic hair follicle development in cashmere goats.BMC veterinary research · 2026Article
- Sesamin alleviates androgenetic alopecia by targeting the AR MAPK Wnt axis.Scientific reports · 2026Article
- Precision therapeutics in non-scarring alopecia: a systemic genomic and pathway-based framework for targeted interventions.ADMET & DMPK · 2026Review
- Synergistic effects of mesenchymal stem cell secretome and Wnt10b on hair follicle regeneration in a 3D bioengineering model: a preclinical study.Stem cell research & therapy · 2025Article
- Recent Advances in the Role of Fibroblast Growth Factors in Hair Follicle Growth.Biomolecules · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Hair follicles play an important role in maintaining the normal functions of the skin. The dynamic and alternating changes of diverse molecular signals determine hair follicle development and regeneration in the skin. Among the signals, Wnts, particularly Wnt10b is characterized to be especially important in regulating hair follicle behavior by specifically activating the canonical Wnt/β-catenin signaling pathway. In this review, we review the role of Wnt10b signaling in hair growth and regeneration. During embryonic development, Wnt10b promotes hair morphogenesis by inducing the formation of dermal papilla. Moreover, Wnt10b/β-catenin signaling not only governs the fate of hair follicle stem cells (HFSCs) but also coordinates HFSCs and melanocyte stem cells to facilitate pigmented hair regeneration. Interestingly, during wound healing, epidermis-derived Wnt10b initiates hair follicle neogenesis by promoting the dedifferentiation of epidermal keratinocytes and inducing the formation of dermal papilla. However, prolonged overexpression of Wnt10b in epidermal keratinocytes is associated with early-stage cell transformation, the occurrence of systemic sclerosis, and even the development of skin neoplasms. Therefore, a deeper understanding of the role of Wnt10b signaling in hair follicle development, regeneration, and skin diseases provides a rational basis for the development of translational medicine.
Indexed as
Identifiers
40512432What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.