Evidence map›Paper›PMID 40512419›Full record

ArticleObesity surgery2025

Cognitive Improvement Following Bariatric Surgery is Associated with Enhanced Hippocampal Activation and Reduction in Visceral and Ectopic Fat Deposition.

Yanjie Duan, Wenhuan Feng, Xitai Sun, Bing Zhang, Zhou Zhang, Yingwen Miao, Tianyu Wu, Wen Zhang, Wenhui Zhu, Xuewei Tong and 2 more

Abstract read
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In one paragraph

Article in Obesity surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yanjie DuanDepartment of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China.
Wenhuan FengBranch of National Clinical Research Centre for Metabolic Diseases, Nanjing, China.
Xitai SunDepartment of Pancreatic and Metabolic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Bing ZhangDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Zhou ZhangBranch of National Clinical Research Centre for Metabolic Diseases, Nanjing, China.
Yingwen MiaoBranch of National Clinical Research Centre for Metabolic Diseases, Nanjing, China.
Tianyu WuBranch of National Clinical Research Centre for Metabolic Diseases, Nanjing, China.
Wen ZhangDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Wenhui ZhuBranch of National Clinical Research Centre for Metabolic Diseases, Nanjing, China.
Xuewei TongBranch of National Clinical Research Centre for Metabolic Diseases, Nanjing, China.
Xin LiDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Yan BiDepartment of Endocrinology, Endocrine and Metabolic Disease Medical Center, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, China. biyan@nju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence has demonstrated that patients with obesity exhibited cognitive impairment and cerebral damage. Bariatric surgery is an effective intervention for obesity and is associated with cognitive improvement. However, the underlying mechanisms by which bariatric surgery improves cognitive function remain unclear. This study aimed to evaluate cognitive alterations in patients with obesity before and after bariatric surgery, and to further explore the associations among fat reduction, cognitive alterations, and underlying cerebral changes.

methodsWe conducted an exploratory study on 23 patients with obesity who underwent bariatric surgery. These patients received anthropometric measurements, detailed cognitive assessments, and functional magnetic resonance imaging (fMRI) scans at baseline and 12 months post-surgery to evaluate neuroimaging and cognitive changes.

resultsCompared to baseline, patients with obesity exhibited significant improvements in immediate and delayed memory following bariatric surgery. fMRI scans also revealed increased left hippocampal volume and enhanced right hippocampal activation in patients with obesity postoperatively. Furthermore, these improvements in cognitive function and hippocampal activation were associated with reductions in visceral fat (β = -0.122, 95% bootstrap CI: -0.210, -0.030) and hepatic steatosis (β = -0.147, 95% bootstrap CI: -0.266, -0.053) in the mediation analysis.

conclusionThis study showed that bariatric surgery significantly reduced fat deposition and improved cognitive function in patients with obesity. Importantly, the improvement in brain functional activation played a key role in alleviating cognitive impairment, underscoring its vital importance in cognitive health.

Indexed as

Bariatric SurgeryCognitionCognitive DysfunctionHippocampusIntra-Abdominal FatObesity, MorbidAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedTreatment OutcomeWeight LossBariatric surgeryCognitive improvementEctopic fatHippocampal activationVisceral fat

Identifiers

PMID40512419

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.