Evidence map›Paper›PMID 40512394›Full record

ArticleCalcified tissue international2025

Characterization of Bone Matrix Mineralization and Osteocyte Lacunar Density Unveils Microstructural Impairment at the Main Femoral Fracture-Initiating Site in Type 2 Diabetes Mellitus.

Aleksandar Cirovic, Jelena Jadzic, Christine Plumeyer, Danica Djukic, Vladimir Zivkovic, Slobodan Nikolic, Danijela Djonic, Marija Djuric, Björn Busse, Petar Milovanovic

Abstract read
PubMed Publisher
In one paragraph

Article in Calcified tissue international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aleksandar CirovicCenter of Bone Biology, Institute of Anatomy, Faculty of Medicine, University of Belgrade, Dr Subotica 4/2, Belgrade, Serbia.
Jelena JadzicCenter of Bone Biology, Institute of Anatomy, Faculty of Medicine, University of Belgrade, Dr Subotica 4/2, Belgrade, Serbia.
Christine PlumeyerDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Lottestrasse 55a, Hamburg, Germany.
Danica DjukicInstitute of Forensic Medicine, Faculty of Medicine, University of Belgrade, Deligradska 31a, Belgrade, Serbia.
Vladimir ZivkovicInstitute of Forensic Medicine, Faculty of Medicine, University of Belgrade, Deligradska 31a, Belgrade, Serbia.
Slobodan NikolicInstitute of Forensic Medicine, Faculty of Medicine, University of Belgrade, Deligradska 31a, Belgrade, Serbia.
Danijela DjonicCenter of Bone Biology, Institute of Anatomy, Faculty of Medicine, University of Belgrade, Dr Subotica 4/2, Belgrade, Serbia.
Marija DjuricCenter of Bone Biology, Institute of Anatomy, Faculty of Medicine, University of Belgrade, Dr Subotica 4/2, Belgrade, Serbia.
Björn BusseDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Lottestrasse 55a, Hamburg, Germany.
Petar MilovanovicCenter of Bone Biology, Institute of Anatomy, Faculty of Medicine, University of Belgrade, Dr Subotica 4/2, Belgrade, Serbia. drpmilovanovic@gmail.com.ORCID http://orcid.org/0000-0003-1461-8437

Funding

Science Fund of the Republic of Serbia BoFraMScience Fund of the Republic of Serbia grant no. 7749444
6 · The paper itself

Abstract

This study aimed to perform microstructural characterization of the increased fragility of human bone in type 2 diabetes mellitus (T2DM) by exploring the matrix mineralization and osteocyte lacunar density at the superolateral femoral neck-the typical fracture-initiating site. Postmortem specimens of the full-length superolateral femoral neck from 16 elderly men with T2DM and age-matched non-DM controls were examined using backscattered-electron microscopy in terms of mineralization parameters and parameters of osteocyte lacunar density. The T2DM and control groups did not differ in age and body mass index (p > 0.05). In the endocortical region, T2DM was associated with a lower degree of mineralization (lower CaMean: p = 0.04), a higher proportion of extremely low-mineralized areas (higher CaLow: p = 0.027), and greater mineralization heterogeneity (higher CaWidth: p = 0.003) relative to controls. However, there were no significant intergroup differences in mineralization parameters in the periosteal region. In the endocortical region, T2DM showed lower unmineralized (p = 0.006) and total osteocyte lacunar number (Lc.N) per bone area (B.Ar) (p = 0.018) coupled with a higher percentage of mineralized lacunae (%Mn.Lc) relative to controls (p = 0.05). In the periosteal region, only Lc.N/B.Ar was lower in T2DM (p = 0.004). As for the trabecular compartment, T2DM was associated with lower trabecular CaMean (p = 0.048) and higher trabecular CaLow and CaWidth (p = 0.005, p = 0.007). Altered pattern of mineralization in the cortical (especially in the endocortical region) and trabecular compartments of the superolateral femoral neck and reduced cortical osteocyte lacunar density are structural hallmarks of bone fragility in T2DM.

Indexed as

Bone MatrixCalcification, PhysiologicDiabetes Mellitus, Type 2OsteocytesAgedAged, 80 and overBone DensityFemur NeckHumansMaleMiddle AgedMineralizationSuperolateral femoral neckType 2 diabetes mellitus

Identifiers

PMID40512394

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.