Trial reportLangenbeck's archives of surgery2025
Chlorhexidine - coated vs non-coated Suture to prevent surgical site infections following laparoscopic abdominal surgery (a prospective, randomized, controlled trial; NOVOTILAC).
Trial report in Langenbeck's archives of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04033211 (Randomized, Multi-center, Double Blinded, Prospective Study to Evaluate the Incidence of Complications in Laparoscopic Cholecystectomy and Appendectomy Using Novosyn® CHD Versus Novosyn® Suture Material to Close Trocar Wound), which is not on this map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized, Multi-center, Double Blinded, Prospective Study to Evaluate the Incidence of Complications in Laparoscopic Cholecystectomy and Appendectomy Using Novosyn® CHD Versus Novosyn® Suture Material to Close Trocar Wound
Who cites it
1 citing paper in PubMed.
- Antimicrobial Functionalization of Composite Nanofibrous Yarns as Surgical Sutures.Macromolecular bioscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSurgical site infection (SSI) is the second most frequently reported health-care related infection and is accompanied by significant morbidity and considerable costs. Since cutaneous, bacterial contamination plays an important role, antimicrobial coated threads may - amongst other measures - reduce or prevent SSI.
methodThis international, multicentric, parallel, double-blinded prospective, randomized, controlled trial (RCT) evaluated a new Chlorhexidine-(CHD) coated braided suture material ([Poly(glycolid-co-l-lactid 90/10)]; PGL-CHD) in comparison to the identical non-coated suture material (PGL) to close trocar incisions in patients undergoing laparoscopic appendectomy or cholecystectomy for the prevention of SSI. Primary endpoint was the incidence of SSI one month after surgery. Secondary outcomes were postoperative pain, suture material handling, length of hospital stay, quality of life, aesthetic result and the postoperative complication rate including hernias. Randomization was performed intra-operatively using sealed opaque envelopes. The patient was blinded to the type of suture material & the observer who was involved in the postsurgical wound assessment. Patients were followed up until 12 months after surgery.
resultsIn total, 337 patients were enrolled, 323 randomized, whereby 161 cases received PGL-CHD & 162 PGL suture material. One month follow-up examination was completed in 297 individuals. SSI rate in the whole population was 5%. In total 10 SSI occurred in the uncoated suture group (10/162; 95%CI: 6.17% [3.26-11.12%]) and 6 in the coated group (6/158; 95% CI: 3.79% [1.57-8.22%]), p = 0.44. Surgical handling of both suture materials was rated as very good and the pain level decreased from preoperative to postoperative and patients were pain-free 30 days after surgery. The long-term follow-up showed an excellent cosmetic assessment of the wound by the patient as well as by the observer, and an improvement of quality of life over time with no difference in the various suture and indication groups. The overall 1 year hernia rate was low with 0.9%, mean length of hospital stay was reported with 2.90 ± 2.29 days and only a few patients (6/323) were admitted to ICU.
conclusionThe SSI rate in the CHD-coated suture group compared to the uncoated group was lower, but failed to reach significance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.