Evidence map›Paper›PMID 40512391›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2025

Prospective evaluation of low voltage-guided repeat ablation of atrial fibrillation.

Dennis Lawin, Christoph Stellbrink, Sophia Schulze Lammers, Alina Hoffmann, Andrej Teren, Thorsten Lawrenz

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dennis LawinDepartment of Cardiology and Intensive Care Medicine, Bielefeld University, Medical School and University Medical Center OWL, Klinikum Bielefeld - Mitte, Teutoburger Str. 50, 33604, Bielefeld, Germany. dennis.lawin@klinikumbielefeld.de.ORCID http://orcid.org/0000-0002-1292-7845
Christoph StellbrinkDepartment of Cardiology and Intensive Care Medicine, Bielefeld University, Medical School and University Medical Center OWL, Klinikum Bielefeld - Mitte, Teutoburger Str. 50, 33604, Bielefeld, Germany.ORCID http://orcid.org/0000-0002-8429-2826
Sophia Schulze LammersDepartment of Cardiology and Intensive Care Medicine, Bielefeld University, Medical School and University Medical Center OWL, Klinikum Bielefeld - Mitte, Teutoburger Str. 50, 33604, Bielefeld, Germany.ORCID http://orcid.org/0009-0002-5256-1179
Alina HoffmannDepartment of Cardiology and Intensive Care Medicine, Bielefeld University, Medical School and University Medical Center OWL, Klinikum Bielefeld - Mitte, Teutoburger Str. 50, 33604, Bielefeld, Germany.ORCID http://orcid.org/0009-0005-9696-4027
Andrej TerenDepartment of Cardiology and Intensive Care Medicine, Bielefeld University, Medical School and University Medical Center OWL, Klinikum Bielefeld - Mitte, Teutoburger Str. 50, 33604, Bielefeld, Germany.ORCID http://orcid.org/0000-0002-9383-8413
Thorsten LawrenzDepartment of Cardiology and Intensive Care Medicine, Bielefeld University, Medical School and University Medical Center OWL, Klinikum Bielefeld - Mitte, Teutoburger Str. 50, 33604, Bielefeld, Germany.ORCID http://orcid.org/0000-0002-2930-8493

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) recurrences following pulmonary vein isolation (PVI) remain a substantial challenge.

aimsTo evaluate repeat ablation of AF combining PVI with substrate-based left atrial ablation targeting low voltage areas (LVA).

methodsPatients with recurrent AF after prior solely PVI were enrolled. Voltage map was conducted during sinus rhythm. Repeat PVI was performed in case of PV-reconnection. Only if LVA (defined as electrogram amplitudes < 0.5 mV) were present, substrate modification was conducted by creating linear or box lesions. Arrhythmia monitoring was performed for 6 months using a photoplethysmography-based smartphone application.

results58 patients were analysed (37.9% female, median age 66.0 years [IQR 59.8-72.3]). Reconnection of at least 1 PV was found in 49 patients (84.5%). LVA were found in 31 patients (53.4%). An anterior box lesion was created in 39.7%, anterior linear lesion in 8.6%, posterior box lesion in 17.2%, roof line in 34.5%, and posterior mitral isthmus line in 5.2% of the patients. Patients with LVA were more often female (54.8% vs. 18.5% without LVA; p = 0.0045), were at higher age (71.0 years [IQR 66.0-78.0] vs. 62.0 years [IQR 55.0-66.0] without LVA; p < 0.0001), and had higher left atrial volume indexes (50.0ml/m

conclusionPV reconnection and the presence of LVA constitute the main findings of repeat ablations of AF. Repeat PVI combined with a tailored ablation approach individually targeting LVA was effective and safe.

Indexed as

Atrial fibrillationLow voltageRadiofrequencyRepeat ablationSubstrate

Identifiers

PMID40512391

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.