Evidence map›Paper›PMID 40512379›Full record

ArticleNeuroradiology2025

Accuracy of computational fluid dynamics indices of unruptured cerebral aneurysms with 3 T magnetic resonance angiography.

Futoshi Mori, Mikito Saito, Kentaro Fujimoto, Yoshitaka Kubo, Takahiro Koji, Yosuke Akamatsu, Kuniaki Ogasawara, Tsuyoshi Matsuda, Ikuko Uwano, Fumio Yamashita and 2 more

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Article in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Futoshi MoriDivision of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Yahaba, Japan. fumori@iwate-med.ac.jp.
Mikito SaitoDepartment of Stroke and Cerebrovascular Medicine, Kyorin University Faculty of Medicine, Mitaka, Japan.
Kentaro FujimotoDepartment of Neurosurgery, Iwate Medical University, Yahaba, Japan.
Yoshitaka KuboDepartment of Neurosurgery, Iwate Medical University, Yahaba, Japan.
Takahiro KojiDepartment of Neurosurgery, Iwate Medical University, Yahaba, Japan.
Yosuke AkamatsuDepartment of Neurosurgery, Iwate Medical University, Yahaba, Japan.
Kuniaki OgasawaraDepartment of Neurosurgery, Iwate Medical University, Yahaba, Japan.
Tsuyoshi MatsudaDivision of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Yahaba, Japan.
Ikuko UwanoDivision of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Yahaba, Japan.
Fumio YamashitaDivision of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Yahaba, Japan.
Ryoichi TanakaDivision of Dental Radiology, Department of Reconstructive Oral and Maxillofacial Surgery, Iwate Medical University, Yahaba, Japan.
Makoto SasakiDivision of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Yahaba, Japan.

Funding

Grant-in-Aid for Strategic Medical Science Research S1491001JSPS KAKENHI JP16K20024JSPS KAKENHI JP17H04304
6 · The paper itself

Abstract

purposeComputational fluid dynamics (CFD) analysis has been applied to predict the rupture of cerebral aneurysms, and results suggest that wall shear stress (WSS) and related metrics can be imaging markers for the risk of rupture. Computed tomography angiography (CTA) is commonly used as source images for CFD analyses. However, it remains unknown whether less-invasive magnetic resonance angiography (MRA) can be used as a substitute for CTA. Hence, we investigated if CFD metrics calculated from MRA were comparable to those calculated from CTA in cerebral aneurysms.

methodsSixty-three patients with 86 unruptured aneurysms who underwent MRA at 3T and CTA were retrospectively enrolled between 2012 and 2018 from a prospective cohort study. We performed CFD analyses to obtain indices including the WSS, WSS gradient (WSSG), and oscillatory shear index (OSI) of aneurysmal walls and compared these values between MRA and CTA.

resultsStatistically significant correlations and agreements were observed between MRA and CTA for the mean/minimum WSS, mean/minimum WSSG, and maximum OSI values (correlation coefficient = 0.60–0.79, intraclass correlation coefficient = 0.62–0.79). However, the mean OSI value exhibited suboptimal correlation and agreement (0.48 and 0.31, respectively). Multivariate regression analyses further revealed significant negative correlations between discrepancies in the mean WSS/WSSG between MRA and CTA and the aneurysm angle.

conclusionExcept for the mean OSI, CFD values of unruptured cerebral aneurysms obtained from 3T MRA showed good correlations and agreements with those from CTA, indicating that 3T MRA can be partly applied for CFD analyses of cerebral aneurysms.

Indexed as

Cerebral AngiographyIntracranial AneurysmMagnetic Resonance AngiographyAgedComputed Tomography AngiographyFemaleHumansHydrodynamicsMaleMiddle AgedRetrospective StudiesComputational fluid dynamicsComputed tomography angiographyIntracranial aneurysmMagnetic resonance angiographyWall shear stress

Identifiers

PMID40512379

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