ArticleNeuroradiology2025
Detection of cerebral cavernous malformation associated developmental venous anomalies in gradient-echo and susceptibility-weighted magnetic resonance imaging: can we skip the contrast?
Article in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Developmental venous anomalies on fetal magnetic resonance imaging: prevalence and reproducible radiological phenotypes.Pediatric radiology · 2026Article
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Authors and funding
15 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeHemosiderin-sensitive MRI sequences are commonly utilized for microbleed identification in cerebral cavernous malformations (CCM). Efficacy of susceptibility-weighted (SWI) and gradient-echo T2*-weighted imaging (GRE-T2*) sequences in detecting CCM-associated developmental venous anomalies (DVA) remains uncertain.
methodsWe conducted a retrospective review of our institutional CCM database. Inclusion criteria comprised baseline characteristics and MRI datasets involving contrast-enhanced T1 (CE-T1), T2, and SWI or GRE-T2* sequences. The presence of CCM-related DVA was determined utilizing CE-T1 imaging. A subgroup of 200 patients, evenly distributed with or without DVA, underwent random selection for analysis, with 50 patients each having SWI and GRE-T2* imaging. The presence of DVA was evaluated by two blinded neuroradiologists based on SWI or GRE-T2* sequences. Interrater agreement, sensitivity, and specificity values for SWI and GRE-T2* sequences were analyzed.
resultsImaging assessment demonstrated observer agreement in 76% of the SWI sequences (K = 0.51, p <0.001) and 82% of the GRE-T2* images (K = 0.39, p <0.001). While SWI sequences exhibited a sensitivity of 81.4% and a specificity of 60.6%, GRE-T2* sequences showed a sensitivity of 19.1% and a specificity of 97.5%. Misdiagnoses were frequent in small vessel DVAs, whereas large vessel DVAs were associated with higher diagnostic accuracy in both SWI and GRE-T2* sequences (p =0.002).
conclusionEvaluation of SWI and GRE-T2* sequences for assessing CCM-related DVA appears less effective than the routine use of CE-T1 sequences. The use of contrast agents still appears necessary for detailed diagnostics and appropriate surgery planning.
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