ReviewBiological trace element research2026
Lead-Induced Nephrotoxicity and Its Therapeutic Interventions: An Updated Review.
Review in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Article
- Effects of Flammable and Non-Flammable Nicotine Products on Kidney Health.Medical sciences (Basel, Switzerland) · 2026Review
- Sulfur-Containing Amino Acid Homeostasis in the Central Nervous System: From Physiology Regulation to Metal-Induced Neurotoxicity.Metabolites · 2026Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lead is a major environmental pollutant and a poisonous substance that induces oxidative stress. It is responsible for several serious diseases associated with its toxicity. Its presence in the environment mostly affects children, mining workers, and pregnant women. Multiple studies are underway to investigate the mechanisms of lead-induced renal damage and associated diseases. Several mechanisms contribute to lead-induced nephrotoxicity, resulting in nephron damage and eventually inducing acute kidney injury (AKI) and chronic kidney disease (CKD). Chelation therapy is currently the main approach for the treatment of lead toxicity. However, recent research is increasingly exploring the potential of naturally occurring bioactive compounds, plant-derived extracts, and nanotechnology-based strategies as alternative treatments for lead poisoning. This review focuses on the mechanistic effects of toxicity and the various categories of compounds that have a beneficial impact on lead-induced renal toxicity. Plant extracts are significant in mitigating lead intoxication. A combination of phyto-bioactive and chelating agents is used for the treatment of lead toxicity. Cerium- and selenium-derived nanoparticles are used for therapeutic purposes. Further research is required to investigate the therapeutic potential of these therapeutic interventions.
Indexed as
Identifiers
40512368What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.