Evidence map›Paper›PMID 40512342›Full record

ArticleMolecular diversity2026

Quinazolinone based broad-spectrum antiviral molecules: design, synthesis, in silico studies and biological evaluation.

Abdallah E Abdallah, Omkulthom Al Kamaly, Esmail M El-Fakharany, Yousra A El-Maradny, Abdelaaty A Shahat, Mohamed S Alesawy, Ali Hammad, Mohamed Ayman El-Zahabi, Samiha A El-Sebaey, Mona S El-Zoghbi

Abstract read
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In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Abdallah E AbdallahPharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt. abdulla_emara@azhar.edu.eg.
Omkulthom Al KamalyDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, 11671, Riyadh, Saudi Arabia.
Esmail M El-FakharanyProtein Research Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg AL-Arab, 21934, Alexandria, Egypt.
Yousra A El-MaradnyProtein Research Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg AL-Arab, 21934, Alexandria, Egypt.
Abdelaaty A ShahatPharmacognosy Department, College of Pharmacy, King Saud University, P.O. Box 2457, 11451, Riyadh, Saudi Arabia.
Mohamed S AlesawyPharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt.
Ali HammadDepartment of Pharmaceutical Organic Chemistry, College of Pharmacy, Al-Azhar University, Cairo, Egypt.
Mohamed Ayman El-ZahabiPharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, 11884, Egypt.
Samiha A El-SebaeyDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Youssef Abbas Street, Nasr City, Cairo, Egypt. samiha.ali85@azhar.edu.eg.
Mona S El-ZoghbiDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Menoufia University, Shibin-Elkom, Gamal Abd Al-Nasir Street, Menoufia, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In an attempt to develop broad-spectrum antiviral agents, we designed non-nucleoside small molecules as deubiquitinating enzyme inhibitors. The newly developed candidates are based on the quinazolinone nucleus and have been biologically evaluated as antiviral agents against four viruses: adenovirus, HSV-1, coxsackievirus, and SARS-CoV-2. Additionally, activity against papain-like protease (PL

Indexed as

Antiviral AgentsQuinazolinonesAdenoviridaeCoronavirus 3C ProteasesCoronavirus Papain-Like ProteasesCOVID-19 Drug TreatmentDrug DesignHerpesvirus 1, HumanHumansMolecular Docking SimulationSARS-CoV-2Structure-Activity RelationshipAntiviral AgentsCoronavirus 3C ProteasesCoronavirus Papain-Like ProteasesQuinazolinonesAntiviralPapain like proteaseQuinazolinoneSARS-CoV-2

Identifiers

PMID40512342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.