Evidence map›Paper›PMID 40512316›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2025

Methods for Evaluation of Antivirals and Neutralizing Antibodies Against Tick-Borne Encephalitis Virus.

Ludek Eyer, Pavel Svoboda, Martin Palus, Jiri Salat, Daniel Růžek

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ludek Eyer *Faculty of Science, Masaryk University, Brno, Czech Republic.
Pavel Svoboda *Faculty of Science, Masaryk University, Brno, Czech Republic.
Martin Palus *Institute of Parasitology, Biology Centre of the Czech Academy of Science, Ceske Budejovice, Czech Republic.
Jiri SalatFaculty of Science, Masaryk University, Brno, Czech Republic.
Daniel RůžekFaculty of Science, Masaryk University, Brno, Czech Republic. ruzekd@paru.cas.cz.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tick-borne encephalitis (TBE) is a potentially fatal neuroinfection of humans caused by the TBE virus. There is no specific therapy for TBE, as treatment is only supportive. Therefore, efforts to develop an effective specific therapy for TBE are warranted. Small molecule inhibitors and monoclonal antibodies are under intense investigation as potential therapeutics to combat TBE in humans. Here we describe the basic methods that can be used to test small molecule antivirals or monoclonal antibodies against TBEV. These include in vitro methods such as plaque assays, neutralizing assays, immunofluorescence staining of viral antigen, and cell-based antiviral assays, as well as in vivo assays in mouse model of TBE.

Indexed as

Antibodies, NeutralizingAntibodies, ViralAntiviral AgentsEncephalitis, Tick-BorneEncephalitis Viruses, Tick-BorneAnimalsAntibodies, MonoclonalCell LineDisease Models, AnimalHumansMiceNeutralization TestsViral Plaque AssayAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralAntiviral AgentsAntiviralsImmunofluorescenceMonoclonal antibodiesMouse infectionNeutralization testPlaque assayTick-borne encephalitis virus

Identifiers

PMID40512316

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.