Human Skin Ex Vivo Culture for Tick-Borne Virus Infection Studies.

Dakota N Paine, Jessica Crooker, Saravanan Thangamani

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dakota N PaineDepartment of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY, USA.

Jessica CrookerDepartment of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY, USA.

Saravanan ThangamaniSUNY Center for Vector-Borne Diseases, SUNY Upstate Medical University, Syracuse, NY, USA. thangams@upstate.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tick-borne viral infections, like those described in this book, pose real threats to the health of humans across the world. Powassan virus (POWV) and Deer tick virus (DTV) are two examples of tick-borne flaviviruses that are endemic to North America and cause neuroinvasive disease. These two viruses are both genetically similar and are spread by similar vectors but have differing tropism and clinical outcomes. Studies involving these viruses have routinely consisted of mouse models and in vitro studies. These models, effective as they are, are limited in their use as they are either costly or do not meet niche needs. Herein, we describe a method of using an ex vivo human skin model for infection studies that focus on the primary site of infection, the skin.

Indexed as

Encephalitis Viruses, Tick-BorneSkinTick-Borne DiseasesAnimalsHumansDeer tick virusHuman skinPowassan virusTick-borne diseaseTick-borne virus

Identifiers

PMID40512308

DOI10.1016/j.xjidi.2022.100128

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.