Evidence map›Paper›PMID 40512292›Full record

ArticleHormones (Athens, Greece)2025

Investigating hormonal imbalances in aggressive periodontitis: a scoping review.

Zahra Khorshidi Asl, Fatemeh Farshad, Farnaz Jafari, Georgios Romanos, Mahshid Hodjat

Abstract readScoping Review
PubMed Publisher
In one paragraph

Article in Hormones (Athens, Greece), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zahra Khorshidi AslStudents Research Committee, Shiraz Dental School, Shiraz University of Medical Sciences, Shiraz, Iran.ORCID http://orcid.org/0009-0002-7487-5785
Fatemeh FarshadDental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences (TUMS), Tehran, 1417614411, Iran.ORCID http://orcid.org/0000-0002-4928-2358
Farnaz JafariOral and Dental Diseases Research Center, Kerman University of Medical Sciences, Kerman, Iran.ORCID http://orcid.org/0000-0003-0278-3048
Georgios RomanosDepartment of Periodontics and Endodontics, Laboratory for Periodontal-, Implant-, Pathology (La-PIP), Stony Brook University, Pathology (La-PIP), Stony Brook, NY, USA.
Mahshid HodjatDental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences (TUMS), Tehran, 1417614411, Iran. mhodjat@TUMS.ac.ir.ORCID http://orcid.org/0000-0001-8335-3546

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to consolidate the existing literature on the role of hormones in aggressive periodontitis. A systematic search was carried out in July 2024 in the following databases: National Library of Medicine MEDLINE/PubMed, Scopus, Web of Science, and Google Scholar, using the related keywords to aggressive periodontitis, hormone, insulin, thyroid hormones, cortisol, calcitonin, growth hormone, osteocalcin, parathyroid hormone, TSH, melatonin, vitamin D, stress hormones, adrenomedullin, glucagon, growth factor, and somatostatin. No filters were applied during the search. Conference abstracts, editorials, case reports, and review articles were not considered. Of 258 records identified in the databases, 27 records were selected for this study. While the current literature supports the imbalances in levels of melatonin, growth factors, adrenomedullin, procalcitonin, leptin, osteocalcin, cortisol, and vitamin D in aggressive periodontitis patients, controversy remains regarding the role of some of these hormones in the pathology of periodontitis. Moreover, there is a need for additional research to explore the interplay between these hormones and aggressive periodontitis. Future studies may also uncover novel therapeutic applications of hormones in managing the condition.

Indexed as

Aggressive PeriodontitisHormonesHumansHormonesAggressive periodontitisCortisolHormoneMelatoninOsteocalcinVitamin D

Identifiers

PMID40512292

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.