ArticleNeurochemical research2025
Hydroxysafflor Yellow A Ameliorates Ischemic Stroke by Inhibiting NLRP3, AIM2, and Pyrin Inflammasome-Mediated Pyroptosis.
Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Echinacoside Attenuates LPS-induced Neuroinflammation and Ameliorates Memory Deficit by Modulating the Microbiota-Gut-Brain Axis.Journal of microbiology and biotechnology · 2026Article
- Pharmacology-Driven Dissection of Core Component Sets of Xuefu Zhuyu Decoction in Blood Stasis-Related Cardiovascular Diseases.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Hydroxysafflor yellow a attenuates oxygen-glucose deprivation/ reoxygenation induced endothelial pyroptosis via PARP-1/NLRP3 pathway.Frontiers in pharmacology · 2026Article
- Molecular Mechanisms and Clinical Applications of Buyang Huanwu Decoction in the Treatment of Ischemic Stroke: A Review.International journal of general medicine · 2026Review
- Aquaporin-4 suppresses neuronal pyroptosis after ischemic stroke via the IκBα/NF-κB signaling pathway.Frontiers in immunology · 2026Article
- Neuroprotective potential of indian herbs in ischaemic stroke: a comprehensive review of pharmacological insights, therapeutic gaps, and future directions.Inflammopharmacology · 2025Review
- Discovery of (Molecules (Basel, Switzerland) · 2025Article
- Hypoxia-inducible factor 1-alpha: a dual regulator of ferroptosis in ischemic stroke and a promising therapeutic target.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Hydroxysafflor Yellow A (HSYA), a water-soluble compound derived from the traditional Chinese medicine Carthamus tinctorius L., is known for its protective effects against cerebral ischemia/reperfusion(I/R) injury, though its mechanism remains unclear. This study investigated the effect of HSYA on cerebral I/R injury and its potential relation to pyroptosis. Adult male Sprague-Dawley rats were divided into sham-operated, model, and HSYA-treated groups. HSYA was administered as a pretreatment for 5 days before constructing the cerebral I/R injury model. Neurological function scores, TTC staining, HE staining, Nissl staining, immunofluorescence staining, SOD, GSH, GSH-Px, MDA, LDH Assays, PCR, western blotting, and ELISA were used to assess HSYA's effects. HSYA pretreatment improved neurological deficits and pathological state of brain tissue and reduced infarct area. It raised SOD, GSH, and GSH-Px activities, along with reduced MDA and LDH levels. Immunofluorescence staining and western blotting revealed that HSYA effectively inhibited the expression of NLRP3, AIM2, Pyrin, Cleaved-Caspase1, GSDMD, ASC, and HMGB1-related proteins. Additionally, ELISA results demonstrated that HSYA suppressed the release of IL18 and IL-1β inflammatory factors in serum. These findings suggest HSYA may alleviate ischemic stroke injury by inhibiting NLRP3, AIM2, and Pyrin inflammasome-mediated pyroptosis, offering a potential therapeutic strategy for cerebral I/R injury.
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Registered trials
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