Evidence map›Paper›PMID 40512243›Full record

ArticleJournal of materials science. Materials in medicine2025

Synergistic effects of polydopamine-coated reduced graphene oxide on osteogenesis and anti-inflammation in periodontitis.

Xiaoge Jiang, Xinyi Chen, Qiming Li, Xinyi Li, Kaiwen Zhang, Jiazhen Jiang, Xinrui Men, Wei-Cho Chiou, Song Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials science. Materials in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoge JiangState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Xinyi ChenState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Qiming LiState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Xinyi LiState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Kaiwen ZhangState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Jiazhen JiangState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Xinrui MenState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Wei-Cho ChiouState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Song ChenState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China. songchen882002@hotmail.com.ORCID http://orcid.org/0000-0001-7185-0123

Funding

Science and Technology Department of Sichuan Province 2022YFS0127
6 · The paper itself

Abstract

Owing to its extremely high prevalence and the distressing consequence of tooth loss, periodontitis has attracted substantial research attention. In light of these conditions, graphene-based biomaterials have emerged as a potentially promising approach for periodontal regeneration. This study focuses on the synthesis of polydopamine-coated reduced graphene oxide (RGO@PDA), designed to harness the anti-inflammatory properties of dopamine and the osteogenic potential of graphene oxide for synergistic periodontitis treatment. RGO@PDA was synthesized through a 12-h magnetic stirring process of graphene oxide and dopamine at room temperature. This water-dispersible and biocompatible compound demonstrated remarkable efficacy in enhancing osteogenic differentiation in rat bone mesenchymal stem cells (rBMSCs), evidenced by increased alkaline phosphatase activity, mineralization, and the upregulation of osteogenic genes and proteins. Furthermore, RGO@PDA showed significant capabilities in scavenging reactive oxygen species (ROS) and reducing proinflammatory factor expression. In vivo experiments revealed that RGO@PDA not only alleviated periodontal inflammation but also promoted alveolar bone repair in periodontitis-afflicted rats. These findings underscore RGO@PDA's dual anti-inflammatory and osteogenic effects, highlighting its potential as a transformative treatment for periodontitis.

Indexed as

Anti-Inflammatory AgentsGraphiteIndolesOsteogenesisPeriodontitisPolymersAnimalsCell DifferentiationCoated Materials, BiocompatibleMaleMesenchymal Stem CellsRatsRats, Sprague-DawleyReactive Oxygen SpeciesAnti-Inflammatory AgentsCoated Materials, Biocompatiblegraphene oxideGraphiteIndolespolydopaminePolymersReactive Oxygen SpeciesAnti-inflammationGraphene oxideOsteogenesisPeriodontitisPolydopamine

Identifiers

PMID40512243
PMCPMC12165884

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.