Evidence map›Paper›PMID 40512182›Full record

ArticleCellular and molecular life sciences : CMLS2025

Endothelial CHOP as a central mechanism in renovascular hypertension-induced vascular endothelial dysfunction and cardiac fibrosis.

B Srinivas, K Alluri, P Fortuno, M Rizzi, H Suhail, N Rhaleb, K Matrougui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

B SrinivasDepartment of Physiological Sciences, EVMS, Norfolk, VA, 23501, USA.
K AlluriDepartment of Physiological Sciences, EVMS, Norfolk, VA, 23501, USA.
P FortunoDepartment of Physiological Sciences, EVMS, Norfolk, VA, 23501, USA.
M RizziDepartment of Physiological Sciences, EVMS, Norfolk, VA, 23501, USA.
H SuhailDepartment of Physiology, Wayne State University, Detroit, MI, 48202, USA.
N RhalebDepartment of Physiology, Wayne State University, Detroit, MI, 48202, USA.
K MatrouguiDepartment of Physiological Sciences, EVMS, Norfolk, VA, 23501, USA. matrouk@evms.edu.ORCID http://orcid.org/0000-0001-9269-2937

Funding

Ac-SDKP in the Treatment of Cardiac Dysfunction in Hypertension or Ischemic HeartR01HL136456 · NHLBI · WAYNE STATE UNIVERSITY · PI RHALEB, NOUR-EDDINE · 2018 to 2021
$1.9M
Interleukin 12 disruption provides beta cell and microvessel protection in type 2diabetesR01HL150014 · NHLBI · OLD DOMINION UNIVERSITY · PI MATROUGUI, KHALID · 2020 to 2023
$1.8M
Stromal interaction molecule 1, immune cells, and vascular pathology in established hypertensionR01HL151616 · NHLBI · OLD DOMINION UNIVERSITY · PI MATROUGUI, KHALID · 2020 to 2023
$1.5M
NHLBI NIH HHS R01 HL136456NHLBI NIH HHS R01 HL150014NHLBI NIH HHS R01 HL151616NIH HHS HL136456NIH HHS HL150014NIH HHS HL151616
6 · The paper itself

Abstract

objectiveIn this study, we sought to determine the significant impact of the vascular endothelial endoplasmic reticulum (ER) stress C/EBP homologous protein (CHOP) in renovascular hypertension-induced vascular endothelial dysfunction and cardiac fibrosis. APPROACH AND

resultsEight-week-old male and female CHOP

conclusionOur research findings determined that CHOP is a central mechanism driving vascular endothelial dysfunction and cardiac fibrosis in renovascular hypertension. Therefore, targeting CHOP in endothelial cells could be a potential therapeutic approach to protect against the pathogenesis of renovascular hypertension.

Indexed as

Endothelium, VascularHypertension, RenovascularMyocardiumTranscription Factor CHOPAngiotensin IIAnimalsCardiomegalyEndoplasmic Reticulum StressEndothelial CellsFemaleFibrosisHumansMaleMiceMice, Inbred C57BLMice, KnockoutAngiotensin IIDdit3 protein, mouseNitric Oxide Synthase Type IIITranscription Factor CHOPCardiac fibrosisCHOPEndothelial dysfunctionInflammationRenovascular hypertension

Identifiers

PMID40512182
PMCPMC12165939

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.