Evidence map›Paper›PMID 40512052›Full record

ArticleAntimicrobial agents and chemotherapy2025

Proteogenomic analysis demonstrates increased

Lisa M Meekes, Astrid P Heikema, Manuela Tompa, Ana L Astorga Alsina, Saskia D Hiltemann, Andrew P Stubbs, Lennard J M Dekker, Dimard E Foudraine, Nikolaos Strepis, Johann D D Pitout and 3 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Molecular Insights into Carbapenem Resistance inInternational journal of molecular sciences · 2026
    Review
  3. Article
  4. Harnessing interpretable deep learning to predict resistance inFrontiers in cellular and infection microbiology · 2026
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lisa M MeekesDepartment of Medical Microbiology & Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID 0009-0002-6140-2575
Astrid P HeikemaDepartment of Medical Microbiology & Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Manuela TompaCentral Laboratory, Regional Institute of Gastroenterology and Hepatology "Prof. Dr. Octavian Fodor", Cluj-Napoca, Romania.
Ana L Astorga AlsinaDepartment of Medical Microbiology & Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Saskia D HiltemannDepartment of Pathology and Clinical Bioinformatics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.ORCID 0000-0003-3803-468X
Andrew P StubbsDepartment of Pathology and Clinical Bioinformatics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Lennard J M DekkerDepartment of Neurology, Clinical and Cancer Proteomics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Dimard E FoudraineDepartment of Medical Microbiology & Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Nikolaos StrepisDepartment of Medical Microbiology & Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Johann D D PitoutDepartment of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Gisele PeiranoDepartment of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
C H W KlaassenDepartment of Medical Microbiology & Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
W H F GoessensDepartment of Medical Microbiology & Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Funding

Eurostars 974
6 · The paper itself

Abstract

Antimicrobial resistance arises from complex genetic and regulatory changes, including single mutations, gene acquisitions, or cumulative effects. Advancements in genomics and proteomics facilitate a more comprehensive understanding of the mechanisms behind antimicrobial resistance. In this study, 74 clinically obtained

Indexed as

Anti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenemsKlebsiella pneumoniaePorinsHumansImipenemKlebsiella InfectionsMeropenemMicrobial Sensitivity TestsMutationPlasmidsProteogenomicsTandem Mass SpectrometryWhole Genome SequencingAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasescarbapenemaseCarbapenemsImipenemMeropenemOmpK36 protein, Klebsiella pneumoniaePorinsantimicrobial resistanceKlebsiellamass spectrometryOmpK36OXA-48porins

Identifiers

PMID40512052
PMCPMC12217476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.