ArticleObesity (Silver Spring, Md.)2025
Modeling potential cost-effectiveness of tirzepatide versus lifestyle modification for patients with overweight and obesity.
Article in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Development of Cardiovascular Risk Equations in People with Overweight or Obesity and Established Cardiovascular Disease Without Diabetes Based on the SELECT Trial.PharmacoEconomics · 2026Trial
- GLP-1 Receptor Agonist Therapy for Obesity Under Japan's Optimal Use Guideline: A Prospective Real-World Study of Lifestyle Pre-Treatment, Time-Limited Treatment Cap, and Post-Cessation Regain.Diabetes, obesity & metabolism · 2026Article
- Modeling potential cost-effectiveness of tirzepatide versus lifestyle modification for patients with overweight and obesity.Obesity (Silver Spring, Md.) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
objectiveOur objective was to model the potential cost-effectiveness of tirzepatide as an alternative to lifestyle modification (LSM) for the management of obesity and overweight.
methodsAn individual-level discrete event simulation was implemented in Microsoft Excel linking short-term outcomes from the SURMOUNT-1 trial to key obesity-related complications to estimate costs and health benefits of tirzepatide (5-mg, 10-mg, or 15-mg doses) and LSM over a lifetime time horizon. Treatment-related changes in cardiometabolic factors were modeled using data from SURMOUNT-1; the relationship between patient status and risk of obesity complications was obtained from published literature. Modeled complications included cardiovascular events, onset of type 2 diabetes, cancer, osteoarthritis, and sleep apnea. The model simulated 1000 adult patients with overweight or obesity over their lifetimes, applying a 3% annual discount rate to cost and health outcomes. Only direct medical costs were considered.
resultsTirzepatide 5, 10, and 15 mg provided 0.54, 0.55, and 0.61 additional quality-adjusted life years (QALYs) and additional costs of $79,288, $70,453, and $75,839 versus LSM, yielding incremental cost-effectiveness ratios of $146,331, $127,644, and $125,053 per QALY gained, respectively.
conclusionsThe model predicted that all doses of tirzepatide represent cost-effective alternatives to LSM for management of overweight and obesity at a willingness-to-pay threshold of $150,000 per QALY.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.