The challenging approach to the management of male partners of HPV-positive women.

Human papillomavirus (HPV) is the most prevalent sexually transmitted infection globally, with significant implications for both individual and public health. While management protocols for HPV-positive women are well-defined, limited and controversial guidance exists for their male partners, creating challenges in clinical practice. This commentary aims to turn the attention to the clinical, psychological, and preventive considerations for male partners of HPV-positive women, emphasizing the need for evidence-based recommendations. It presents the psychological impact of HPV on couples, and the role of preventive measures such as vaccination. Key focus areas included partner notification, HPV testing in men, and risk-reduction strategies. HPV infections in male partners can lead to conditions ranging from genital warts to HPV-associated cancers. Despite the absence of routine HPV testing for men, targeted interventions, including vaccination, have demonstrated effectiveness in reducing HPV transmission and associated cancer risks. The management of male partners of HPV-positive women remains an underexplored and controversial domain, necessitating the development of comprehensive, evidence-based guidelines. Integrating vaccination, partner counseling, and targeted clinical approaches could address existing gaps and ensure equitable care for both partners.