ArticlemSystems2025
Multi-level regulation of hindgut homeostasis by volatile fatty acid administration in dairy goats: linking microbial metabolism to epithelial inflammation and barrier function.
Article in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Effects of esculetin on growth performance, carcass traits, intestinal morphology, digestive enzyme, barrier function and cecal microbiota in broiler chickens.Poultry science · 2026Article
- Differential Regulation of Ruminal Microbial Community Structure and Functional Pathways in Sheep Supplemented with Linseed Oil or Sunflower Oil.Animals : an open access journal from MDPI · 2026Article
- Unraveling the dynamic changes in the intestinal microbiome: impacts on pre-weaning calf health and productivity.Journal of animal science and biotechnology · 2026Review
- Article
- First insights into the physiological status and gut microbiota of free-grazing Tibetan goats in Kangding, Western China.Journal of advanced veterinary and animal research · 2026Article
- Comparative analysis of cecal microbiota and metabolites in relation to growth performance of Tibetan and Hu sheep.Frontiers in microbiology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
This study provided a comprehensive exploration of the nutritional regulation of volatile fatty acids (VFAs) on hindgut microbial metabolism and epithelial homeostasis in dairy goats. Twenty-four goats were orally administered sodium acetate (SA) at 0.8 g/kg of body weight (BW), propionate (SP) at 0.8 g/kg of BW, butyrate (SB) at 0.5 g/kg of BW, or saline (CON) before morning feeding for 12 days ( IMPORTANCE: The volatile fatty acids (VFAs), mainly produced by rumen microbiota, play an important role in ruminal metabolic functions and epithelial health, but their impact on the hindgut has received limited attention. Our study highlighted the significant role of VFAs in hindgut bacterial metabolism and homeostasis, providing novel insights into the role of VFAs in regulating hindgut metabolism and physiological homeostasis beyond the rumen.
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Registered trials
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