Evidence map›Paper›PMID 40511936›Full record

ArticlemSystems2025

Trade-off between resistance and persistence in high cell density cultures.

F Beulig, J Bafna-Rührer, P E Jensen, S H Kim, A Patel, V Kandasamy, C Steffen, K Decker, D Zielinski, L Yang and 3 more

Abstract read
In one paragraph

Article in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Phages and quorum sensing: findings to consider in phage therapy.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

F BeuligNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID 0009-0008-5377-8461
J Bafna-RührerNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
P E JensenNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
S H KimNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
A PatelDepartment of Bioengineering, University of California, San Diego, California, USA.
V KandasamyNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
C SteffenNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
K DeckerDepartment of Bioengineering, University of California, San Diego, California, USA.
D ZielinskiNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
L YangNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
E ÖzdemirNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
S SudarsanNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID 0000-0002-2985-1728
B PalssonNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID 0000-0003-2357-6785

Funding

Novo Nordisk Fonden NNF10CC1016517Novo Nordisk Fonden NNF20CC0035580
6 · The paper itself

Abstract

Bacterial growth to high cell densities is commonly observed in infections, microbiomes, and biomanufacturing, yet there is limited understanding of how transcriptional regulation changes to balance between growth and survival under associated stresses. Here, we utilized well-controlled culturing systems to grow wild-type and metabolically engineered

Indexed as

Escherichia coliGene Expression Regulation, BacterialMachine LearningMetabolic EngineeringStress, PhysiologicalTranscriptomeEscherichia colihigh cell density physiologypersistenceresistancestimulons

Identifiers

PMID40511936
PMCPMC12282090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.