Evidence map›Paper›PMID 40511889›Full record

Observational studyANZ journal of surgery

A Retrospective Study on Use of Neutrophil-Lymphocyte Ratio as a Prognostic Measurement to Assess Acute Diverticulitis.

Yam Ting Ho, Omattage M Perera, Femi E Ayeni, Harrison Gregory, Hugh McMahon, Punkaja M S Amarasekera, Yi-Che Chan, Jia Han Chang, Tzu Yi Chuang, Peter J Coverdale

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in ANZ journal of surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yam Ting HoDepartment of Surgery, Ipswich Hospital, Ipswich, Australia.ORCID 0009-0006-2812-1818
Omattage M PereraDepartment of Surgery, Ipswich Hospital, Ipswich, Australia.ORCID 0000-0001-5854-1836
Femi E AyeniNepean Institute of Academic Surgery, Nepean Clinical School, The University of Sydney, Kingswood, Australia.ORCID 0000-0002-6827-0088
Harrison GregoryDepartment of Surgery, Ipswich Hospital, Ipswich, Australia.
Hugh McMahonDepartment of Surgery, Ipswich Hospital, Ipswich, Australia.
Punkaja M S AmarasekeraDepartment of Surgery, Ipswich Hospital, Ipswich, Australia.
Yi-Che ChanDepartment of Surgery, Ipswich Hospital, Ipswich, Australia.
Jia Han ChangDepartment of Surgery, Ipswich Hospital, Ipswich, Australia.
Tzu Yi ChuangDepartment of Surgery, Ipswich Hospital, Ipswich, Australia.
Peter J CoverdaleDepartment of Surgery, Ipswich Hospital, Ipswich, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute diverticulitis (AD) is a common surgical condition and the Neutrophil-lymphocyte ratio (NLR) is an emerging biomarker ratio used to guide its management. The aim of this study is to validate and assess the utility of the NLR in AD in the Australian population.

methodsThis is a single centre retrospective observational study of patients who presented to the emergency department with the diagnosis of AD between September 2018 and September 2023, in Ipswich, Queensland. One thousand five hundred and forty patients were screened against exclusion/inclusion criteria and 634 patients were available for analysis.

resultsThe study identified NLR, CRP (C-reactive protein) and age to be significant coefficients in predicting length of stay (LOS) in regression analysis. NLR (OR1.06, p < 0.001) and CRP (OR1.01, p < 0.001) were significant predictors for surgical management of diverticulitis. NLR was found to be superior predictor of surgical management in ROC analysis (AUC 0.75, sensitivity 65%, specificity 75%, p < 0.001) compared to CRP, but both were equivalent in predicting for diverticulitis severity and percutaneous drainage. Further analysis revealed NLR between those receiving surgery, percutaneous drainage and readmission (One-way ANOVA) and NLR between modified Hinchey classifications were also significantly different (Mann-Whitney U).

conclusionIn this study, we have further validated the effectiveness of NLR as a diagnostic marker. In particular, NLR is superior to CRP in predicting surgical management. It has also proven useful to predict for LOS, disease severity and percutaneous drainage. NLR usage should be encouraged in the clinical setting as it is simple and effective.

Indexed as

DiverticulitisDiverticulitis, ColonicLymphocytesNeutrophilsAcute DiseaseAdultAgedAged, 80 and overBiomarkersC-Reactive ProteinFemaleHumansLength of StayLeukocyte CountLymphocyte CountMaleBiomarkersC-Reactive Proteinclinical decision‐makingdiagnostic techniques and proceduresdiverticulitishealth status indicator

Identifiers

PMID40511889
PMCPMC12413579

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.