ArticleCurrent medical imaging2025
Altered Grey Matter Volume and Cerebral Perfusion over the Whole Brain in Painful Temporomandibular Disorders: A Pilot Voxel-Based Analysis.
Article in Current medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Localized surface-based morphometric differences in painful temporomandibular disorder.Neuroimage. Reports · 2026Article
- Global research trends in MRI of temporomandibular disorders: a bibliometric study and visualization analysis via CiteSpace.Journal of oral & facial pain and headache · 2025Article
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3 authors.
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Abstract
backgroundPain with a persistent and recurrent onset is one of the most important symptoms of temporomandibular disorders (TMD). Recent evidence indicated the dysfunction of the central nervous system was more linked to TMD pain. This study aimed to explore the abnormal structural and perfusion alterations in patients with painful TMD (p-TMD) to understand the comprehension of neuro-pathophysiological mechanisms.
methodsForty-one p-TMD patients and 33 normal controls (NC) were recruited, and high-resolution structural brain and 3D PCASL data were obtained from a 3.0T MR scanner. The voxel-based analysis of the whole cerebral gray matter (GMV) was performed, and the GMV and cerebral blood flow (CBF) value of the altered positive areas were extracted to investigate the significant correlation with clinical variables.
resultsThe brain regions with significantly increased GMV in p-TMD group were listed as follows: right putamen, right superior frontal gyrus, left superior frontal gyrus medial segment, right supplementary motor cortex, left postcentral gyrus, right middle temporal gyrus, right postcentral gyrus medial segment, right temporal pole, right inferior temporal gyrus and right opercular part of the inferior frontal gyrus (Punc<0.001, cluster>39). However, there were no brain regions with significantly decreased GMV in the p-TMD group. Cerebral perfusion analysis identified that only the right postcentral gyrus medial segment presented significantly higher CBF value in the p-TMD group than in the NC group over all the brain regions with increased GMV. Within the p-TMD group, pain intensity, anxiety, depression, and jaw functional limitation scores were differentially associated with GMV and CBF value.
conclusionThe voxel-based morphometric and perfusion findings collectively implicate maladaptive plasticity in both the sensory-discriminative and affective-motivational dimensions of pain processing in p-TMD pathophysiology.
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