ArticleInvestigative radiology2026
Free-Breathing Hybrid Technique for Simultaneous Morphological and Quantitative Abdominal Imaging at 0.55 T.
Article in Investigative radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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7 authors.
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Abstract
objectivesQuantitative proton density fat fraction (PDFF) and R2* estimation at lower field strengths, such as 0.55 T, is challenging due to lower signal-to-noise ratio, reduced fat water chemical shift, and increased T2* relaxation times. In this study, we propose a 3D hybrid technique for abdominal imaging at 0.55 T that enables the simultaneous acquisition of T2-weighted and T1-weighted images and quantification of fat fraction and R2* parameters. MATERIALS AND
methodsNumerical simulations were performed to optimize a prototype radial hybrid turbo spin echo gradient echo (TSE-GRE) acquisition scheme for improved PDFF and R2* estimation accuracy. Phantom imaging experiments with and without motion were performed to evaluate the sensitivity of the estimation to external motion. Eleven volunteers were imaged on a prototype 0.55 T system. Data were acquired using the proposed technique under free-breathing conditions, and motion-compensated reconstruction was performed using the respiratory signal from a pilot-tone device. Image contrast and estimation performance were compared with conventional acquisition schemes in vitro and in vivo.
resultsNumerical simulations indicated R2* estimation accuracy was more sensitive to the choice of echo time compared with PDFF. Performing motion compensation reduced the mean error in R2* from 24 to 5 s -1 while the mean error in PDFF only reduced from 2.7% to 1.6%. The proposed technique generated T2-weighted images with comparable relative liver-spleen contrast as conventional imaging and there were no significant differences ( P >0.05) in the PDFF and R2* values estimated from the hybrid technique compared with conventional multi-echo GRE. Further, the free-breathing acquisition allowed improved slice coverage while overcoming breath-hold limitations of conventional acquisition schemes.
conclusionsThe use of a hybrid TSE-GRE acquisition technique can allow simultaneous morphological and quantitative PDFF and R2* estimation at 0.55 T under free-breathing conditions.
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