ArticleEuropean journal of neurology2025
Nerve Diameter and DTI Parameters Maybe Potential Markers for Clinical Trial in Patients With Charcot-Marie-Tooth Disease Type 1A.
Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundCharcot-Marie-Tooth disease type 1A (CMT1A) is the most common form of CMT, varying from asymptomatic to severe. The aim of this study was to investigate whether the diffusion tensor imaging (DTI) parameters and diameter of the proximal nerves, as measured by magnetic resonance neurography, can be used as a potential marker to reflect the progression.
methodsThis was a prospective study including 45 consecutive patients with CMT1A, divided into three subgroups by foot dorsiflexion muscle strength: mild cases (Group 1), moderate cases (Group 2), and severe cases (Group 3). We compared the diameter, fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) of the L4-L5 nerve roots, femoral nerve (FN), and sciatic nerve (SN) of patients with CMT1A with those of healthy controls (HCs), and among subgroups. We followed 19 patients for 15 months and analyzed the change.
resultsThe diameters of the L4 nerve roots and SN were significantly larger in Group 3 than in Group 1 and HCs. FA was decreased and MD and AD were increased significantly in Group 3 compared to Group 1, with the differences being more pronounced in SN and L4 nerve roots. After the follow-up period, the diameters, FA, MD, AD, and RD of the nerve roots were changed significantly.
conclusionsNerve diameter, FA, MD, and AD on DTI could be sensitive measures reflecting disease severity and progression in patients with CMT1A, prominently in proximal nerve roots. SN and L4 nerve roots may be suitable indices.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.