Evidence map›Paper›PMID 40511587›Full record

ArticleAllergy2025

A Growing Concern for Cashew and an Unexpected Risk From Almonds: Data From the Anaphylaxis Registry.

Veronika Höfer, Sabine Dölle-Bierke, Dominique Sabouraud-Leclerc, Amandine Divaret-Chauveau, Alice Köhli, Maria Breiding, Karin Hartmann, Lars Lange, Nikolaos Papadopoulos, Hagen Ott and 4 more

Abstract read
In one paragraph

Article in Allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Taste aversion and adverse events contribute equally to OIT discontinuation in children: A real-world multi-allergen analysis.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Veronika HöferDivision of Allergy and Immunology, Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID https://orcid.org/0000-0002-8538-3439
Sabine Dölle-BierkeDivision of Allergy and Immunology, Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID https://orcid.org/0000-0002-3339-0709
Dominique Sabouraud-LeclercPresidency on Behalf of Allergy Vigilance Network, Vandoeuvre les Nancy, France.ORCID https://orcid.org/0009-0002-1517-4137
Amandine Divaret-ChauveauUR 3450 DevAH - Department of Physiology, Health Faculty, University of Lorraine, Vandœuvre-les-Nancy, France.ORCID https://orcid.org/0000-0002-2492-9864
Alice KöhliDivision of Paediatric Allergology, Department of Pediatrics, Children's Hospital Lucerne, Lucerne, Switzerland.ORCID https://orcid.org/0000-0002-8091-7454
Maria BreidingDivision of Allergy, University Children's Hospital and Children's Research Center, University of Zurich (UZH), Zurich, Switzerland.ORCID https://orcid.org/0009-0009-1934-5205
Karin HartmannDivison of Allergy, Department of Dermatology, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0002-4595-8226
Lars LangeDepartment of Paediatrics, St. Marien-Hospital, Bonn, Germany.ORCID https://orcid.org/0000-0003-1104-5848
Nikolaos PapadopoulosDepartment of Allergy, 2nd Paediatric Clinic, University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0002-4448-3468
Hagen OttDivision of Pediatric Dermatology and Allergology, Children's Hospital Auf der Bult, Hannover, Germany.ORCID https://orcid.org/0000-0003-1792-3947
Stephanie HompesDepartment of Paediatrics, Altona Children's Hospital, Hamburg, Germany.ORCID https://orcid.org/0009-0006-1056-6413
Maria Beatrice BilòDepartment of Clinical and Molecular Sciences, Università, Politecnica Delle Marche, Ancona, Italy.ORCID https://orcid.org/0000-0002-9324-6039
Blanca E GarcíaAllergology Service, Hospital Universitario de Navarra, Pamplona, Spain.ORCID https://orcid.org/0000-0003-4463-4841
Margitta WormDivision of Allergy and Immunology, Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID https://orcid.org/0000-0002-3449-1245

Funding

Bundesministerium für Bildung und Forschung 01EA2107BDeutsche Forschungsgemeinschaft 409525714EU-H2020-MSCA-COFUND EURIdoc programme 101034170NORA e.VSwiss National Science Foundation (SNSF) 310030_207705The Swiss Cancer Research Foundation KFS-5979-08-2023
6 · The paper itself

Abstract

backgroundFood allergies are a major health concern with rising prevalence. Dietary habits are changing, and information about cashew-induced anaphylaxis is limited.

methodsCases of tree nut-induced anaphylaxis (TIA) registered from 2007 until April 2024 were extracted from the European Anaphylaxis Registry and analyzed.

results1389 cases of TIA out of 5945 registered food-induced reactions (23%) were identified. 1,083 cases with confirmed elicitor status, including 845 children (median age 4 years, 61% male) and 238 adults (38 years, 40% male), were selected for further analysis. The most frequent elicitors among children were cashew (n = 334), hazelnut (n = 211) and walnut (n = 146). The proportion of cashew-induced anaphylaxis increased from 2007 to 2024, and reactions were frequently caused by small amounts (< 1 teaspoon). Adults reacted frequently to hazelnut (n = 105), walnut (n = 47) but also almond (n = 35) and to higher amounts. Potential cofactors were present in 50% of the adult patients and 17% of children. The reaction severity was age-independent, and only a minority of patients was previously aware of their allergy (children 23%, adults 21%). The use of adrenaline was low in lay treatment (children 13%, adults 3%) and reached approximately 40% upon professional treatment.

conclusionCashew is an increasing, relevant allergen leading to anaphylaxis and is now the most frequent cause of TIA among children. These findings highlight the need for effective prevention and treatment measures. Almond was a frequent elicitor among adults and should be further monitored. The acute management requires improvement to comply with current guidelines.

Indexed as

AnacardiumAnaphylaxisNut HypersensitivityPrunus dulcisAdolescentAdultAgedAllergensChildChild, PreschoolFemaleHumansInfantMaleMiddle AgedRegistriesAllergensalmond allergycashew allergyEuropean Anaphylaxis Registryhazelnut allergytree nut anaphylaxis

Identifiers

PMID40511587
PMCPMC12486339

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.