Evidence map›Paper›PMID 40511585›Full record

ArticleJournal of cachexia, sarcopenia and muscle2025

Patients Having Major Abdominal Cancer Surgery Exhibit Significant Acute Muscle Wasting.

Gabor Dudas, Ismita Chhetri, Martin Whyte, Margaret Rayman, Rachel Simmonds, Anthony Catchpole, Mark Griffiths, Ben Creagh-Brown

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In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gabor DudasFaculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Ismita ChhetriFaculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Martin WhyteFaculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Margaret RaymanFaculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Rachel SimmondsFaculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Anthony CatchpoleScottish Trace Element and Micronutrient Diagnostic and Research Laboratory, Glasgow Royal Infirmary, Glasgow, UK.
Mark GriffithsWilliam Harvey Institute, Queen Mary University of London, London, UK.
Ben Creagh-BrownFaculty of Health and Medical Sciences, University of Surrey, Guildford, UK.ORCID 0000-0002-4397-1232

Funding

Royal Surrey NHS Foundation Trust
6 · The paper itself

Abstract

backgroundPostoperative myopenia (acute muscle loss) is a significant concern following major cancer resection surgery, contributing to prolonged recovery, increased dependency and impaired quality of life. Despite its clinical relevance, the mechanisms underlying postoperative myopenia and its potential mediators remain poorly understood. This study aims to evaluate the acute changes in muscle size, strength and activity following major cancer surgery and to explore the role of insulin resistance and selenium deficiency as potential mediators of these alterations.

methodsA prospective cohort study was conducted involving 52 patients undergoing elective open major abdominal surgery for cancer. Preoperative and postoperative assessments included measurements of rectus femoris cross-sectional area (RFCSA) via ultrasound, handgrip strength (HGS), sniff nasal inspiratory pressure (SNIP) and physical activity using an accelerometer. Blood samples were analysed for markers of muscle metabolism, systemic inflammation, insulin resistance and selenium levels. Statistical analyses were performed to compare preoperative and postoperative values and to explore correlations between these measures and clinical outcomes.

resultsA significant reduction in RFCSA was observed in 50% of patients, with a median decrease of 10.2% within the first week post-surgery, which persisted at the 6-week follow-up. HGS and SNIP also showed significant declines postoperatively, and reduced physical activity was associated with greater muscle loss. Insulin resistance and postoperative selenium depletion were associated with greater reductions in RFCSA.

conclusionMajor cancer surgery is associated with significant acute muscle loss, which is not fully recovered by 6 weeks postoperatively. Insulin resistance and selenium deficiency may contribute to this muscle loss. Further research is needed to investigate potential interventions to prevent or mitigate postoperative myopenia.

Indexed as

AbdomenMuscular AtrophyNeoplasmsPostoperative ComplicationsAgedFemaleHumansInsulin ResistanceMaleMiddle AgedProspective Studiescancer surgeryinsulin resistancemuscle lossmuscle wastingmyopeniapostoperative recovery

Identifiers

PMID40511585
PMCPMC12163515

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.