Evidence map›Paper›PMID 40511540›Full record

ArticleJournal of cachexia, sarcopenia and muscle2025

Association of Serum Uric Acid With Relative Muscle Loss: A US Population-Based Cross-Sectional Study.

Fuquan Wang, Lin Wen, Xiaopeng Guo, Weiwei Wang, Yanyan Cao, Guofeng Zhou, Jun Wang, Chuansheng Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fuquan WangDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lin WenDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xiaopeng GuoDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Weiwei WangDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yanyan CaoDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Guofeng ZhouDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jun WangSchool of Food and Drug, Shenzhen Polytechnic University, Shenzhen, China.
Chuansheng ZhengDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0002-2435-1417

Funding

Fundamental Research Funds for the Central Universities YCJJ20251404National Key R&D Program of China 2023YFC2413500
6 · The paper itself

Abstract

backgroundEvidence regarding serum uric acid (SUA) and sarcopenia remains insufficient and controversial. Muscle mass is a basic and objective component of sarcopenia, and relative muscle loss has been used to define sarcopenia in some studies. We sought to investigate the association of SUA levels with relative muscle loss in the National Health and Nutrition Examination Survey (NHANES) 2011-2018.

methodsRelative muscle loss was defined by the Foundation for the National Institutes of Health (FNIH) as characterized by appendicular lean mass (ALM) adjusted by BMI (ALM/BMI) < 0.512 for women and < 0.789 for men. Multivariate logistic regression models were performed, and sample weights were accounted to reflect the nationally representative estimates. Restricted cubic spline regression was performed to visualize the dose-response relationship.

resultsA total of 8967 individuals (mean age 39.4 ± 0.3 years, female 50.1%) were included, with a mean SUA of 5.3 ± 0.02 mg/dL; 762 patients with relative muscle loss (weight prevalence 7.1%) were identified, and participants in the highest quintile of SUA exhibited the highest prevalence, up to 10.5%, while participants in the lowest quintile presented the lowest prevalence (5.3%). After adjusting for sociodemographic, behavioural factors, morbidities and renal function related indicators, participants in the highest quintile of SUA levels presented an elevated risk of relative muscle loss, with OR of 1.78 (95% CI: 1.24, 2.56), as compared with the lowest quintile. This association remained stable across most subgroups, and stronger associations were observed in groups with BMI < 25 kg/m

conclusionsIn summary, this study revealed that elevated SUA levels are a potentially independent risk factor of relative muscle loss among the US adults. Clinical screening for SUA levels may contribute to early detection and prevention of muscle loss.

Indexed as

SarcopeniaUric AcidAdultBody Mass IndexCross-Sectional StudiesFemaleHumansMaleMiddle AgedMuscle, SkeletalNutrition SurveysPrevalenceUnited StatesUric Aciddose–response relationshipoxidative stressrelative muscle losssarcopeniaserum uric acid

Identifiers

PMID40511540
PMCPMC12163516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.