Evidence map›Paper›PMID 40511473›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2025

Influenza vaccine effectiveness in Europe and the birth cohort effect against influenza A(H1N1)pdm09: VEBIS primary care multicentre study, 2023/24.

Esther Kissling, Marine Maurel, Francisco Pozo, Gloria Pérez-Gimeno, Silke Buda, Noémie Sève, Lisa Domegan, Mariëtte Hooiveld, Beatrix Oroszi, Iván Martínez-Baz and 28 more

Abstract readMulticenter Study
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Influenza vaccine effectiveness from nine studies during drifted A(H3N2) subclade K predominance, Europe, September 2025 to January 2026.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
  6. Interim vaccine effectiveness against influenza virus among outpatients, France, October 2025 to January 2026.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Esther KisslingThese authors contributed equally to this work and share first authorship.
Marine MaurelThese authors contributed equally to this work and share first authorship.
Francisco PozoCIBER de Epidemiología y Salud Pública (CIBERESP), Institute of Health Carlos III, Madrid, Spain.
Gloria Pérez-GimenoCIBER de Epidemiología y Salud Pública (CIBERESP), Institute of Health Carlos III, Madrid, Spain.
Silke BudaRobert Koch Institute, Berlin, Germany.
Noémie SèveSorbonne Université, INSERM, Institut Pierre Louis d'épidémiologie et de Santé Publique (IPLESP), F75012, Paris, France.
Lisa DomeganHealth Service Executive-Health Protection Surveillance Centre, Dublin, Ireland.
Mariëtte HooiveldNivel, Utrecht, the Netherlands.
Beatrix OrosziNational Laboratory for Health Security, Epidemiology and Surveillance Centre, Semmelweis University, Budapest, Hungary.
Iván Martínez-BazCIBER de Epidemiología y Salud Pública (CIBERESP), Institute of Health Carlos III, Madrid, Spain.
Raquel GuiomarLaboratório Nacional Referência Gripe e outros Vírus Respiratórios, Instituto Nacional de Saúde Doutor Ricardo Jorge, Lisbon, Portugal.
Neus Latorre-MargalefDepartment of Microbiology, Public Health Agency of Sweden, Stockholm, Sweden.
Ivan MlinarićDivision for Epidemiology of Communicable Diseases, Croatian Institute of Public Health, Zagreb, Croatia.
Mihaela LazarNational Influenza Centre, Cantacuzino National Military-Medical Institute for Research and Development, Bucharest, Romania.
Jaume Giménez DuranServicio de Epidemiologia DG Salut Pública, IDISBA (Instituto de Investigaciones Sanitarias de Baleares), Illes Balears, Spain.
Ralf DürrwaldRobert Koch Institute, Berlin, Germany.
Vincent EnoufCentre National de Référence Virus des Infections Respiratoire (CNR VIR), M3P unit, Institut Pasteur Université Paris Cité, Paris, France.
Adele McKennaHealth Service Executive-Health Protection Surveillance Centre, Dublin, Ireland.
Marit de LangeNational Institute for Public Health and the Environment, Centre for Infectious Diseases Control, Bilthoven, the Netherlands.
Gergő TúriNational Laboratory for Health Security, Epidemiology and Surveillance Centre, Semmelweis University, Budapest, Hungary.
Camino Trobajo-SanmartínCIBER de Epidemiología y Salud Pública (CIBERESP), Institute of Health Carlos III, Madrid, Spain.
Verónica GomezEpidemiology Department, Instituto Nacional de Saúde Doutor Ricardo Jorge, Lisbon, Portugal.
Tove Samuelsson HageyDepartment of Microbiology, Public Health Agency of Sweden, Stockholm, Sweden.
Vesna Višekruna VučinaDivision for Epidemiology of Communicable Diseases, Croatian Institute of Public Health, Zagreb, Croatia.
Maria Carmen CherciuNational Influenza Centre, Cantacuzino National Military-Medical Institute for Research and Development, Bucharest, Romania.
Miriam García VazquezSección de Vigilancia Epidemiológica de la Dirección General de Salud Pública, Aragón, Spain.
Annika ErdwiensRobert Koch Institute, Berlin, Germany.
Shirley MasseUnite des Virus Emergents (UVE: Aix-Marseille Univ, Universita di Corsica, IRD 190, Inserm 1207, IRBA), Marseille, France.
Charlene BennettNational Virus Reference Laboratory, University College Dublin, Dublin, Ireland.
Adam MeijerNational Institute for Public Health and the Environment, Centre for Infectious Diseases Control, Bilthoven, the Netherlands.
Katalin KristófInstitute of Laboratory Medicine, Semmelweis University, Budapest, Hungary.
Jesús CastillaCIBER de Epidemiología y Salud Pública (CIBERESP), Institute of Health Carlos III, Madrid, Spain.
Ana Paula RodriguesEpidemiology Department, Instituto Nacional de Saúde Doutor Ricardo Jorge, Lisbon, Portugal.
Sanja Kurečić FilipovićDivision for Epidemiology of Communicable Diseases, Croatian Institute of Public Health, Zagreb, Croatia.
Alina Elena IvanciucNational Influenza Centre, Cantacuzino National Military-Medical Institute for Research and Development, Bucharest, Romania.
Sabrina BacciEuropean Centre for Disease Prevention and Control, Stockholm, Sweden.
Marlena KaczmarekEuropean Centre for Disease Prevention and Control, Stockholm, Sweden.
European primary care VE groupThe members of the European primary care VE group are acknowledged at the end of the article.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IntroductionInfluenza A(H1N1)pdm09, A(H3N2) and B/Victoria viruses circulated in Europe in 2023/24, with A(H1N1)pdm09 dominance. First influenza infections in childhood may lead to different vaccine effectiveness (VE) in subsequent years.AimThe VEBIS primary care network estimated influenza VE in Europe using a multicentre test-negative study.MethodsPrimary care practitioners collected information and specimens from patients consulting with acute respiratory infection. We estimated VE against influenza (sub)type and clade, by age group and by year of age for A(H1N1)pdm09, using logistic regression.ResultsWe included 29,958 patients, with 3,054, 1,053 and 311 influenza A(H1N1)pdm09, A(H3N2) and B cases, respectively. All-age VE against influenza A(H1N1)pdm09 was 52% (95% CI: 44-59). By year of age, VE was 27% (95% CI: -2 to 47) at 44 years with peaks at 72% (95% CI: 52-84) and 54% (95% CI: 41-64) among children and those 65 years and older, respectively. All-age A(H1N1)pdm09 VE against clade 5a.2a was 41% (95% CI: 24-54) and -11% (95% CI: -69 to 26) against clade 5a.2a.1. The A(H3N2) VE was 35% (95% CI: 20-48) among all ages and ranged between 34% and 40% by age group. All-age VE against clade 2a.3a.1 was 38% (95% CI: 1-62). All-age VE against B/Victoria was 83% (95% CI: 65-94), ranging between 70 and 92% by age group.DiscussionThe 2023/24 VEBIS primary care VE against medically attended symptomatic influenza infection was high against influenza B/Victoria, but lower against influenza A(H1N1)pdm09 and A(H3N2). Clade- and age-specific effects may have played a role in the lower A(H1N1)pdm09 VE.

Indexed as

Influenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza B virusInfluenza, HumanInfluenza VaccinesVaccine EfficacyAdolescentAdultAgedChildChild, PreschoolEuropeFemaleHumansInfantMaleInfluenza Vaccinescase-control studyimprintingInfluenzainfluenza vaccinesmulticentre studyvaccine effectiveness

Identifiers

PMID40511473
PMCPMC12164280

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.