ArticleSurgical case reports2025
Gallbladder Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm Consisting of Adenocarcinoma and Neuroendocrine Tumor G2 Diagnosed after Surgery for Acute Cholecystitis: A Case Report and Exome Analysis.
Article in Surgical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Mixed Neuroendocrine-Non-Neuroendocrine Neoplasm (MiNEN) of the Gallbladder. A Case Report From a Low-Resource Setting.Clinical case reports · 2026Article
- Case report: A challenging case of stage IVB mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder treated with extended radical resection including portal vein reconstruction.Frontiers in oncology · 2026Article
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12 authors.
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Abstract
introductionAmong neuroendocrine neoplasms (NENs), non-neuroendocrine and NEN components may rarely coexist, which are referred to as mixed neuroendocrine-non-NENs (MiNENs). Most gallbladder MiNENs are progressive and associated with neuroendocrine carcinoma (NEC), but rarely with neuroendocrine tumor (NET) as a component. To our knowledge, there are 4 reported cases of mixed gallbladder tumors with NET as a component. From the genetic analysis of MiNENs consisting of NEC, MiNEN is believed to have a common origin, as each tumor component shares a common CASE PRESENTATION: A 77-year-old woman presented to our hospital with epigastric pain. An emergency laparoscopic cholecystectomy was performed with a diagnosis of acute gallstone cholecystitis. Pathological examination revealed gallbladder MiNEN (adenocarcinoma + NET G2). Additional surgery was performed, but no residual tumor was found. The patient has been recurrence-free for 36 months after surgery without adjuvant therapy. The origin of the tumor was examined. Macroscopically, adenocarcinoma cells were present on both sides of the NET, while microscopically, some adenocarcinoma cells were positive for neuroendocrine markers (synaptophysin and chromogranin A). Staining for p53 showed wild-type staining with scattered, weakly expressing cells in both tumors. Subsequently, we performed whole-exome sequencing of each tumor component. The results showed that each tumor component shared
conclusionsIn this case report, the tumors shared a common genetic mutation, suggesting that MiNENs with NET components may share a common origin. Furthermore, the NEN component of MiNEN occurring in the gallbladder was associated with a
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