ReviewIndian journal of orthopaedics2025
Exosomes for the Management of Rotator Cuff Injuries: A Systematic Review.
Review in Indian journal of orthopaedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Inhibiting muscle degeneration in rotator cuff tears: integrative biologic approaches targeting regeneration, fibrosis, and metabolism.Stem cells translational medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Rotator cuff injuries (RCIs) are a common musculoskeletal disability affecting daily activities and work performance for millions globally. Current conservative therapies are riddled with limitations. Therefore, this study aims to review the regenerative effects of exosomes derived from mesenchymal stem cells (MSCs) on RCIs and catalogue ongoing clinical trials investigating their effects. Study Objective: The main aim of this study is to compile findings from in vitro, preclinical, and clinical research articles that evaluate the regenerative potential of exosomes derived from different MSCs on injuries to the rotator cuff. Additionally, the secondary objective is to catalogue ongoing clinical trials registered in various clinical trial databases that explore the impact of exosomes on rotator cuff injuries. Search Criteria: A systematic search across four extensive online journal databases until March 2024 was conducted following PRISMA guidelines. The search focused on articles in English using specific terms related to exosomes and RCIs. Eligible studies, including basic science, preclinical, and clinical research, and were assessed by two independent reviewers. Additionally, registered trials were identified from three international clinical trial databases. Results: Four basic science, one basic science and preclinical, and twelve preclinical studies were included in this review. The studies demonstrated that exosomes derived from various stem cells have a strong regenerative capability, whose effects may be further enhanced by adding growth factors, glycoproteins, or other pro-regenerative markers. Conclusion: In vitro and preclinical studies reveal exosomes' regenerative potential for RCIs. Further research, including clinical trials, is needed to assess exosomes' safety and efficacy in RCI management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.