ArticleInterventional pain medicine2025
Herpes zoster prevalence following epidural steroid injections: a retrospective review.
Article in Interventional pain medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- When Pain Relief Backfires: Ramsay Hunt Syndrome after Intra-articular Steroid Injection - A Rare Complication with 6-month Follow-up.Journal of orthopaedic case reports · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Herpes Zoster, or shingles, is an infection caused by the reactivation of the latent Varicella zoster virus within a sensory ganglion, leading to painful skin lesions localized along dermatomes. Patients undergoing pain medicine procedures involving steroids may face an elevated risk of shingles, which can significantly impact their quality of life. Though rare, HZ has been reported following minimally invasive procedures, such as epidural steroid injections. Objectives: We evaluated the prevalence of shingles within 31 days after epidural steroid injections within Mayo Enterprise sites. Methods: A retrospective chart review included all patients who reported a new HZ event within 31 days after receiving an epidural steroid injection. Information on patient demographics, procedure details, and potential risk factors for herpes zoster was assessed using qualitative analysis. Results: A total of 50,270 epidural injections were performed during the analyzed period. After initial screening, 149 patients were included for chart review, and 37 individuals met the inclusion criteria. Within this subgroup, the median age was 72, and 21 patients were female (56.76 %). The mean timeframe from the procedure until onset of symptoms of infection as reported in the medical record was 15.9 days. Among the patients in the study, 24 patients (64.86 %) had an identified immunocompromised status, and 28 (75.68 %) had an incomplete vaccination status at the time of infection. Conclusion: The incidence of HZ following ESI is low. Other risk factors linked to HZ were identified in our cohort, confounding a possible causal relationship. Prospective studies are needed to elucidate any relationship between ESI and HZ.
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