ReviewFrontiers in bioengineering and biotechnology2025
Carbon dots-based drug delivery for bone regeneration.
Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Overcoming Biological Barriers: A Comprehensive Review of Advanced Melatonin Delivery Systems for Therapeutic Applications.International journal of medical sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbon dots (CDs) are a class of nanobiomaterials with significant potential in bone regeneration. Their excellent biocompatibility, tunable fluorescence, high stability, low toxicity, and abundant functional groups make CDs promising candidates for efficient drug delivery and bone tissue regeneration. CDs contribute to targeted drug release, enhance osteogenic differentiation, and interact with cellular components to facilitate bone formation. Recent research highlights the roles of CDs in scaffold-based approaches, offering controlled drug delivery and real-time bioimaging capabilities. This review provides a comprehensive overview of CDs in bone regeneration, with a focus on their synthesis, functionalization, and biomedical applications. It begins by exploring CD synthesis methods, physicochemical properties, and mechanisms of action. Next, it discusses CD-based drug delivery systems and their applications in bone regeneration. Finally, the review highlights the challenges and future perspectives in optimizing CDs for enhanced therapeutic outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.