ArticleJournal of pharmacy & bioallied sciences2025
The Effect of Adjunctive Antimicrobial Therapy on the Clinical Outcomes of Non-Surgical Periodontal Treatment: A Systematic Review.
Article in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Trial
- Systemic Antibiotics as Adjuncts in Periodontal Therapy for Stage III and Stage IV Periodontitis: An Umbrella Review Aligned with the 2018 World Workshop Classification, with AMSTAR-2 Critical Appraisal.Antibiotics (Basel, Switzerland) · 2026Review
- The Effect of Adjunctive Systemic Antibiotics on the Outcomes of Non-Surgical Periodontal Therapy: A Retrospective Cohort Study.Journal of clinical periodontology · 2026Article
- Comparative evaluation of topical and intramuscular coenzyme Q10 application in non-surgical periodontal disease management: A randomized clinical study.Bioinformation · 2026Article
- Macrolide-resistantFrontiers in pediatrics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Nonsurgical periodontal treatment, particularly scaling and root planing (SRP), is essential for managing periodontitis. Adjunctive systemic antibiotics have been proposed to enhance the clinical outcomes of SRP, especially in advanced stages of the disease. This systematic review evaluates the effectiveness of adjunctive systemic antimicrobial therapy on clinical parameters, including probing pocket depth (PPD), clinical attachment level (CAL), and bleeding on probing (BOP). Methods: A systematic search of PubMed was conducted, focusing on randomized controlled trials (RCTs) between 2010 and 2024 that evaluated the use of systemic antibiotics as an adjunct to SRP in patients with stage III/IV periodontitis. The primary outcomes assessed were changes in PPD, CAL, and BOP. Results: Forty-eight studies, including three recent trials, were analyzed. The combination of amoxicillin and metronidazole resulted in significant improvements in clinical outcomes, with notable reductions in PPD and CAL. Two tables summarize these findings. Conclusion: Systemic antibiotics, especially amoxicillin and metronidazole, significantly enhance clinical outcomes when used adjunctively with SRP. Shorter antibiotic regimens may provide similar benefits with fewer side effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.