ArticleJournal of pharmacy & bioallied sciences2025
Comparison of Nebulized Lignocaine and Lignocaine Spray for Attenuation of Pressor Response to Laryngoscopy and Endotracheal Intubation: A Randomized Clinical Study.
Article in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Laryngoscopy and endotracheal intubation trigger significant hemodynamic stress due to sympathetic stimulation. Lignocaine, with its antiarrhythmic and membrane-stabilizing properties, has been explored via different administration routes to mitigate this response, but the optimal route remains debated. Objective: This study compared the effectiveness of nebulized lignocaine versus lignocaine spray in attenuating the hemodynamic response to laryngoscopy and intubation in elective surgical patients under general anesthesia. Methods: A randomized study was conducted on 60 ASA I and II patients (18-60 years). Group N ( Results: Nebulized lignocaine significantly reduced the heart rate ( Conclusion: Nebulized lignocaine was superior in blunting the pressor response, likely due to enhanced mucosal absorption and airway distribution. Its routine use could improve cardiovascular stability during general anesthesia.
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