ArticleJournal of pharmacy & bioallied sciences2025
Study Protocol: Effect of Lifestyle Modification on Sperm DNA Fragmentation Index.
Article in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Oxidative Stress, Sperm DNA Fragmentation, or Both? Optimizing Test Selection in Male Infertility Evaluation.Antioxidants (Basel, Switzerland) · 2026Review
- Cryopreservation increases sperm DNA fragmentation in normozoospermic Libyan men: the role of oxidative stress and the protective effect of melatonin.The Libyan journal of medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Infertility is a growing concern, affecting 8%-12% of reproductive-age couples worldwide. Male infertility accounts for 20%-30% of cases and contributes to 50% of fertility problems. Semen analysis is the traditional method used to assess male fertility, but it may not adequately reflect sperm DNA integrity, which plays a crucial role in successful conception. Increased oxidative stress (OS) and lifestyle factors like obesity, smoking, and alcohol consumption are known to damage sperm DNA, leading to infertility. Sperm DNA fragmentation (SDF) has emerged as a critical parameter for assessing male fertility potential. This study aims to evaluate the impact of lifestyle modifications on sperm DNA fragmentation in men with infertility. Objective: The objectives of this study are to identify male partners exhibiting abnormal semen parameters, with a focus on assessing the impact of lifestyle modifications-such as quitting smoking, reducing alcohol intake, and increasing physical fitness-on sperm DNA fragmentation. Additionally, the study aims to evaluate the role of sperm DNA integrity in the diagnosis of infertility, as sperm DNA fragmentation is increasingly recognized as a critical factor influencing fertility outcomes. By examining these factors, the study seeks to enhance understanding of how lifestyle changes can potentially improve male fertility through the reduction of DNA fragmentation. Materials and Methods: This prospective study will be conducted at Sawangi, Maharashtra, over 6 months. The study will include male patients with sperm abnormalities and high DNA fragmentation enrolled at an IVF center. Semen analysis, DNA fragmentation testing (using the sperm chromatin dispersion test), and a detailed lifestyle questionnaire will be conducted. Participants will receive advice on lifestyle changes, including cessation of smoking and alcohol consumption and encouragement of physical fitness. Post-modification sperm DNA fragmentation levels will be reassessed. Expected Results: A reduction in sperm DNA fragmentation index (DFI) following lifestyle modifications results in improved sperm quality and fertility outcomes. Study Implications: This study will offer valuable insights into the potential benefits of lifestyle changes on male fertility. It will highlight the importance of sperm DNA integrity and provide a diagnostic tool for male infertility.
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