ReviewJournal of pharmacy & bioallied sciences2025
The Role of the Exposome in Aging and Age-Related Diseases: A Comprehensive Review.
Review in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Modeling the Exposome in Murine Cardiovascular Disease.JACC. Basic to translational science · 2026Review
- Aging in a highly polluted world: challenges and solutions to prevent Alzheimer's disease.Archives of toxicology · 2026Review
- Exposome and mental health across the lifespan: research and clinical perspectives.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Exposome influences: a multi-omics perspective on the combined toxic effects of pharmaceuticals and personal care products in Alzheimer's disease.Frontiers in toxicology · 2026Review
- Redox Network Dysfunction: Integrating Ferroptosis and Cuproptosis Across Human Diseases.Antioxidants (Basel, Switzerland) · 2025Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is a very complex process, which is genetically and environmentally driven. Aging and age-related disease onset are strongly dependent on the exposome (all environmental exposures from conception to death). This review focuses on how environmental load accumulated throughout life, possibly through oxidative stress, inflammation, and epigenetic modulation, influence aging. Specific environmental contributors to neurodegenerative diseases like Alzheimer's and Parkinson's and how they have biological impact are explored by us. We also review recent advances performed in exposome research focusing on biomonitoring and multiomics approaches, which allow for novel discovery of the mechanisms for aging related to exposome. We also suggest potential preventive actions that will help to offset the environmental risks and achieve healthy aging. Knowing how the environment plays a role in aging gives the opportunity to develop better strategies to prevent and manage diseases related to age.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.