ArticleJournal of pharmacy & bioallied sciences2025
Study Protocol: Association of Platelet-Rich Plasma (PRP) with Endometrium Thickness and Pregnancy Outcome in Women with Recurrent Implantation Failure (RIF).
Article in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study, conducted in the Wardha district, Recurrent implantation failure (RIF) and thin endometrium are significant challenges in IVF success. Various techniques have been explored to enhance endometrial receptivity. Platelet-rich Plasma (PRP) is an emerging technique that can enhance the endometrium lining and clinical pregnancy rate. This study will demonstrate the effectiveness of the infusion of the Platelet-rich Plasma (PRP) intra utrine for increasing the endometrium lining and compare the success rate in clinical pregnancy outcome in patients after infusing PRP and not infusing PRP undergoing frozen-thawed embryo transfer. Objective: The objective of the study will be to investigate the role of PRP in addressing recurrent implantation failure due to thin endometrium and to assess the success rate of clinical pregnancy outcome in frozen-thawed embryo transfer after inducing PRP in the patient with RIF. Methodology: A total of 190 patients will be selected for the study. The experimental population will be divided into two groups, i.e., 95 patients will be in the Study group, which will be exposed to PRP infusion, and 95 patients will be in the Control group, which will be exposed to the placebo. The study will be conducted on the population with thin endometrium and recurrent implantation failure (RIF) and females below 50 years of age. In this study, the control group and the study group will be compared, and the result of the intervention given to the study group. This study will also demonstrate how PRP is prepared and then injected in the patient. Expected Result: Therefore, the study will demonstrate that PRP improves the endometrium thickness, reduces the recurrent implantation failure, and also increases the clinical pregnancy rate in the patients who are infused with the PRP. It will demonstrate that PRP is very cost-effective as it is an affordable and low-risk adjunct to improve endometrium receptivity.
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