ArticleJournal of pharmacy & bioallied sciences2025
Association of Hyaluronic Acid-Enriched Transfer Medium (HETM) with Clinical Pregnancy Outcome in Women Undergoing Frozen-Thawed Embryo Transfer (FET).
Article in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Hyaluronic Acid Enriched Medium for Embryo Transfer: A Systematic Review and Meta-analysis.JBRA assisted reproduction · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Recurrent implantation failure is one of the most important problems in the assisted reproduction technologies, such as women who want frozen-thawed embryo transfers. Improvements in embryo culture and transfer techniques notwithstanding, success rates for both implantation and clinical pregnancy remain suboptimal for many patients, especially those with repeated implantation failure. In improving the conditions of embryo transfer, therefore, this has become one of the central focuses of fertility research in trying to enhance the chances of successful implantation. Objectives: The objective of this study is to evaluate whether hyaluronic acid-enhanced transfer medium improves implantation and clinical pregnancy rates (CPR) in frozen-thawed embryo transfer cycles as compared to standard transfer medium, taking into account the effects of patient demographics, exposure duration, and ovarian stimulation protocols on outcomes. Expected Result: Women with repeated implantation failure are anticipated to have greater rates of implantation, clinical pregnancy, and live birth when using HETM as opposed to the control group using standard transfer media. Additionally, optimal exposure durations of HETM (60 and 120 min) are anticipated to further improve outcomes. Secondary outcomes, including early pregnancy loss, multiple birth rates, and adverse pregnancy outcomes, will also be assessed. Conclusion: In conclusion Hyaluronic Acid-Enriched Transfer Medium (HETM) has the potential to enhance implantation rates in assisted reproduction, findings of various studies are inconsistent. Its efficacy can be influenced by patient features and treatment protocols. More studies are required to define the most favorable conditions for the application of HETM, particularly in women with recurrent implantation failure, to optimize its advantage in frozen-thawed embryo transfers.
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