Evidence map›Paper›PMID 40510865›Full record

ArticleJBMR plus2025

Tartrate-resistant acid phosphatase augments the bone anabolic response to mechanical loading in male mice.

Bhavik Rathod, Hasmik Jasmine Samvelyan, Suchita Desai, Laura Bock, Nicole Gustafsson, Jianyao Wu, Claes Ohlsson, Per Magnusson, Göran Andersson, Sara H Windahl

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bhavik RathodDivision of Pathology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.ORCID https://orcid.org/0000-0003-1353-0468
Hasmik Jasmine SamvelyanSchool of Medicine, Medical Technology Research Centre, The Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University, CM1 1SQ Chelmsford, United Kingdom.
Suchita DesaiDivision of Pathology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.
Laura BockDivision of Pathology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.
Nicole GustafssonDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, National Pandemic Center, Stockholm, 17165 Solna, Sweden.
Jianyao WuDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Sahlgrenska Academy at The University of Gothenburg, 413 46 Gothenburg, Sweden.ORCID https://orcid.org/0000-0002-1235-8953
Claes OhlssonDepartment of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research, Sahlgrenska Academy at The University of Gothenburg, 413 46 Gothenburg, Sweden.ORCID https://orcid.org/0000-0002-9633-2805
Per MagnussonDivision of Clinical Chemistry, Department of Biomedical and Clinical Sciences, Linköping University, 581 85 Linköping, Sweden.ORCID https://orcid.org/0000-0002-2123-7838
Göran AnderssonDivision of Pathology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.
Sara H WindahlDivision of Pathology, Department of Laboratory Medicine, Karolinska Institutet, 141 52 Huddinge, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tartrate-resistant acid phosphatase (TRAP) is an enzyme predominantly expressed in osteoclasts, where it plays a pivotal role in bone remodeling. Deficiency in TRAP leads to severe skeletal impairments such as osteopetrosis in humans and mice. While mechanical loading is known to promote bone mass and growth, the role of TRAP in this adaptive process remains unclear. Here, we applied axial tibial loading and micro-CT analysis to investigate differences in anabolic response to mechanical loading in 16-wk-old male TRAP KO (TRAP

Indexed as

ACP5bonecartilagegrowth plategrowth plate bridgesmechanical loadingTRAP

Identifiers

PMID40510865
PMCPMC12161494

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.